Zide and Vulvovaginal dryness - a phase IV clinical study of FDA data

Summary:

Vulvovaginal dryness is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are 60+ old, have been taking the drug for 5 - 10 years also take Magnesium, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Vulvovaginal dryness when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Vulvovaginal dryness?

Vulvovaginal dryness is found to be associated with 436 drugs and 517 conditions by eHealthMe. Check the latest studies of Vulvovaginal dryness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 36 people (0.02%) have Vulvovaginal dryness.

Among these 36 people:

How long have people been on Zide when they have Vulvovaginal dryness? *

What is the age of people who have Vulvovaginal dryness when taking Zide? *

What are other drugs people take besides Zide? *

Vitamin D3: 9 people, 25.00%
Vitamin B12: 9 people, 25.00%
Premarin: 9 people, 25.00%
Magnesium: 9 people, 25.00%
Cetirizine Hydrochloride: 8 people, 22.22%
Tirosint: 8 people, 22.22%
Amlodipine Besylate: 8 people, 22.22%
Cephalexin: 8 people, 22.22%
Losartan Potassium: 8 people, 22.22%
Liothyronine Sodium: 8 people, 22.22%

What are other side effects people have besides Vulvovaginal dryness? *

Pain In Extremity: 12 people, 33.33%
Dizziness: 11 people, 30.56%
Urinary Tract Infection: 11 people, 30.56%
Blood Potassium Decreased: 10 people, 27.78%
Ear Pain: 9 people, 25.00%
Bladder Disorder: 9 people, 25.00%
Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 9 people, 25.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 9 people, 25.00%
Cough: 9 people, 25.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 22.22%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 16.67%
Breast Cancer: 4 people, 11.11%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 3 people, 8.33%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.56%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 2 people, 5.56%
High Blood Cholesterol: 2 people, 5.56%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 5.56%
Depression: 2 people, 5.56%
Osteoporosis (bones weak and more likely to break): 2 people, 5.56%
Pain: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Vulvovaginal dryness?

- Check whether Vulvovaginal dryness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vulvovaginal dryness:

Vulvovaginal dryness (436 drugs)

Browse all the conditions that are associated with Vulvovaginal dryness:

Vulvovaginal dryness (517 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.