Zofran and Cyclic vomiting syndrome - a phase IV clinical study of FDA data

Summary:

Cyclic vomiting syndrome is reported as a side effect among people who take Zofran (ondansetron hydrochloride), especially for people who are female, 20-29 old, have been taking the drug for 1 - 2 years also take Ativan, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Cyclic vomiting syndrome when taking Zofran. It is created by eHealthMe based on reports of 93,713 people who have side effects when taking Zofran from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Cyclic vomiting syndrome?

Cyclic vomiting syndrome (prolonged episodes of severe nausea, vomiting) is found to be associated with 32 drugs and 122 conditions by eHealthMe. Check the latest studies of Cyclic vomiting syndrome.

On Jul, 19, 2026

93,713 people reported to have side effects when taking Zofran.
Among them, 23 people (0.02%) have Cyclic vomiting syndrome.

Could Zofran cause Cyclic vomiting syndrome?

Among these 23 people:

How long have people been on Zofran when they have Cyclic vomiting syndrome? *

What is the gender of people who have Cyclic vomiting syndrome when taking Zofran? *

female: 90.48 %
male: 9.52 %

What is the age of people who have Cyclic vomiting syndrome when taking Zofran? *

What are other drugs people take besides Zofran? *

What are other side effects people have besides Cyclic vomiting syndrome? *

Abdominal Pain: 9 people, 39.13%
Pancreatitis (inflammation of pancreas): 7 people, 30.43%
Back Pain: 7 people, 30.43%
Diarrhea: 7 people, 30.43%
Kidney Stones: 7 people, 30.43%
Migraine (headache): 7 people, 30.43%
Muscle Spasms (muscle contraction): 7 people, 30.43%
Gallbladder Disorder: 7 people, 30.43%
Blood Potassium Decreased: 6 people, 26.09%
Fatigue (feeling of tiredness): 5 people, 21.74%

What are the existing conditions these people have? *

Stress And Anxiety: 10 people, 43.48%
Dysmenorrhea (painful menstruation): 5 people, 21.74%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 21.74%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 21.74%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 17.39%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 17.39%
Birth Control: 4 people, 17.39%
Weight Loss: 3 people, 13.04%
Pain: 3 people, 13.04%
Hypovolaemia (a decreased volume of circulating blood in the body): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Zofran and have Cyclic vomiting syndrome?

- Check whether Cyclic vomiting syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zofran:

Zofran (94,987 reports)

Browse all side effects of Zofran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cyclic vomiting syndrome:

Cyclic vomiting syndrome (32 drugs)

Browse all the conditions that are associated with Cyclic vomiting syndrome:

Cyclic vomiting syndrome (122 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ondansetron hydrochloride (the active ingredients of Zofran) and Zofran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.