Zofran and Cystitis interstitial - a phase IV clinical study of FDA data

Summary:

Cystitis interstitial is reported as a side effect among people who take Zofran (ondansetron hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Ondansetron, and have Pain.

The phase IV clinical study analyzes which people have Cystitis interstitial when taking Zofran. It is created by eHealthMe based on reports of 93,713 people who have side effects when taking Zofran from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Cystitis interstitial?

Cystitis interstitial (unknown cause characterized by bladder pain) is found to be associated with 332 drugs and 439 conditions by eHealthMe. Check the latest studies of Cystitis interstitial.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

93,713 people reported to have side effects when taking Zofran.
Among them, 47 people (0.05%) have Cystitis interstitial.

Could Zofran cause Cystitis interstitial?

Among these 47 people:

How long have people been on Zofran when they have Cystitis interstitial? *

What is the gender of people who have Cystitis interstitial when taking Zofran? *

female: 97.87 %
male: 2.13 %

What is the age of people who have Cystitis interstitial when taking Zofran? *

What are other drugs people take besides Zofran? *

What are other side effects people have besides Cystitis interstitial? *

Chronic Kidney Disease: 11 people, 23.40%
Dyspnea (difficult or laboured breathing): 10 people, 21.28%
Joint Pain: 9 people, 19.15%
Pain: 8 people, 17.02%
Urinary Tract Infection: 8 people, 17.02%
Stress And Anxiety: 8 people, 17.02%
Constipation: 8 people, 17.02%
Fever: 7 people, 14.89%
Injury: 6 people, 12.77%
Maternal Exposure During Pregnancy (use of substance during pregnancy): 6 people, 12.77%

What are the existing conditions these people have? *

Pain: 12 people, 25.53%
Stress And Anxiety: 9 people, 19.15%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 12.77%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 10.64%
Infection: 5 people, 10.64%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 10.64%
Constipation: 5 people, 10.64%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 10.64%
Vomiting In Pregnancy: 4 people, 8.51%
Insomnia (sleeplessness): 4 people, 8.51%

* Approximation only. Some reports may have incomplete information.

Do you take Zofran and have Cystitis interstitial?

- Check whether Cystitis interstitial is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zofran:

Zofran (94,987 reports)

Browse all side effects of Zofran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cystitis interstitial:

Cystitis interstitial (332 drugs)

Browse all the conditions that are associated with Cystitis interstitial:

Cystitis interstitial (439 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ondansetron hydrochloride (the active ingredients of Zofran) and Zofran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.