Zofran and Grunting - a phase IV clinical study of FDA data

Summary:

Grunting is reported as a side effect among people who take Zofran (ondansetron hydrochloride), especially for people who are male, 30-39 old, also take Benadryl, and have Mood swings.

The phase IV clinical study analyzes which people have Grunting when taking Zofran. It is created by eHealthMe based on reports of 93,713 people who have side effects when taking Zofran from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Grunting?

Grunting (abnormal, short, deep, hoarse sounds in exhalation that often accompany severe chest pain) is found to be associated with 115 drugs and 265 conditions by eHealthMe. Check the latest studies of Grunting.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

93,713 people reported to have side effects when taking Zofran.
Among them, 19 people (0.02%) have Grunting.

Among these 19 people:

What is the gender of people who have Grunting when taking Zofran? *

female: 10.53 %
male: 89.47 %

What is the age of people who have Grunting when taking Zofran? *

What are other drugs people take besides Zofran? *

What are other side effects people have besides Grunting? *

Dyspnea (difficult or laboured breathing): 14 people, 73.68%
Loss Of Consciousness: 12 people, 63.16%
Pain: 11 people, 57.89%
Hyperhidrosis (abnormally increased sweating): 11 people, 57.89%
Head Injury: 10 people, 52.63%
Abnormal Behavior: 10 people, 52.63%
Eye Irritation: 9 people, 47.37%
Bruxism (habitual grinding of the teeth, typically during sleep): 9 people, 47.37%
Heart Attack: 9 people, 47.37%
Suicidal Ideation: 9 people, 47.37%

What are the existing conditions these people have? *

Mood Swings (an extreme or rapid change in mood): 5 people, 26.32%
Pain: 4 people, 21.05%
Insomnia (sleeplessness): 4 people, 21.05%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 3 people, 15.79%
Gynecomastia (enlargement of the gland tissue of the male breast): 1 person, 5.26%
Agitation (state of anxiety or nervous excitement): 1 person, 5.26%
Aggression: 1 person, 5.26%
Abdominal Pain: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Zofran and have Grunting?

- Check whether Grunting is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zofran:

Zofran (94,987 reports)

Grunting treatments and more:

Grunting (767 reports)

Browse all side effects of Zofran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Grunting:

Grunting (115 drugs)

Browse all the conditions that are associated with Grunting:

Grunting (265 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ondansetron hydrochloride (the active ingredients of Zofran) and Zofran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.