Zofran and Intestinal ischaemia - a phase IV clinical study of FDA data

Summary:

Intestinal ischaemia is reported as a side effect among people who take Zofran (ondansetron hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Dilaudid, and have Pain.

The phase IV clinical study analyzes which people have Intestinal ischaemia when taking Zofran. It is created by eHealthMe based on reports of 93,713 people who have side effects when taking Zofran from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Intestinal ischaemia?

Intestinal ischaemia (decreased supply of oxygenated blood to the intestines) is found to be associated with 676 drugs and 833 conditions by eHealthMe. Check the latest studies of Intestinal ischaemia.

On Aug, 11, 2026

93,713 people reported to have side effects when taking Zofran.
Among them, 75 people (0.08%) have Intestinal ischaemia.

Could Zofran cause Intestinal ischaemia?

Among these 75 people:

How long have people been on Zofran when they have Intestinal ischaemia? *

What is the gender of people who have Intestinal ischaemia when taking Zofran? *

female: 59.15 %
male: 40.85 %

What is the age of people who have Intestinal ischaemia when taking Zofran? *

What are other drugs people take besides Zofran? *

What are other side effects people have besides Intestinal ischaemia? *

Diarrhea: 21 people, 28.00%
Anaemia (lack of blood): 18 people, 24.00%
Hypotension (abnormally low blood pressure): 17 people, 22.67%
Septic Shock (shock due to blood infection): 16 people, 21.33%
Acute Kidney Failure: 16 people, 21.33%
Abdominal Pain: 15 people, 20.00%
Small Intestinal Obstruction (blockage in small intestine): 13 people, 17.33%
Stress And Anxiety: 12 people, 16.00%
Dehydration (dryness resulting from the removal of water): 11 people, 14.67%
Pain: 11 people, 14.67%

What are the existing conditions these people have? *

Pain: 15 people, 20.00%
High Blood Pressure: 9 people, 12.00%
Diarrhea: 8 people, 10.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 9.33%
Diabetes: 5 people, 6.67%
Stomatitis (inflammation of mucous membrane of mouth): 5 people, 6.67%
Vomiting In Pregnancy: 5 people, 6.67%
Metastatic Neoplasm (spreadable cancer tumour): 5 people, 6.67%
Acute Leukaemia (blood cancer): 4 people, 5.33%
Breast Cancer: 4 people, 5.33%

* Approximation only. Some reports may have incomplete information.

Do you take Zofran and have Intestinal ischaemia?

- Check whether Intestinal ischaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zofran:

Zofran (94,987 reports)

Browse all side effects of Zofran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intestinal ischaemia:

Intestinal ischaemia (676 drugs)

Browse all the conditions that are associated with Intestinal ischaemia:

Intestinal ischaemia (833 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ondansetron hydrochloride (the active ingredients of Zofran) and Zofran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.