Zoladex and Hepatic encephalopathy - a phase IV clinical study of FDA data

Summary:

Hepatic encephalopathy is reported as a side effect among people who take Zoladex (goserelin acetate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Casodex, and have Hepatitis b.

The phase IV clinical study analyzes which people have Hepatic encephalopathy when taking Zoladex. It is created by eHealthMe based on reports of 13,593 people who have side effects when taking Zoladex from the FDA, and is updated regularly.

What is Zoladex?

Zoladex has active ingredients of goserelin acetate. It is often used in prostate cancer. eHealthMe is studying from 13,869 Zoladex users. Check the latest studies of Zoladex.

What is Hepatic encephalopathy?

Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure) is found to be associated with 917 drugs and 1,259 conditions by eHealthMe. Check the latest studies of Hepatic encephalopathy.

On Jul, 06, 2026

13,593 people reported to have side effects when taking Zoladex.
Among them, 18 people (0.13%) have Hepatic encephalopathy.

Could Zoladex cause Hepatic encephalopathy?

Among these 18 people:

How long have people been on Zoladex when they have Hepatic encephalopathy? *

What is the gender of people who have Hepatic encephalopathy when taking Zoladex? *

female: 27.78 %
male: 72.22 %

What is the age of people who have Hepatic encephalopathy when taking Zoladex? *

What are other drugs people take besides Zoladex? *

What are other side effects people have besides Hepatic encephalopathy? *

Acute Kidney Failure: 7 people, 38.89%
Hepatic Failure (liver failure): 6 people, 33.33%
Malignant Neoplasm Progression (cancer tumour came back): 5 people, 27.78%
Hepatitis Fulminant (life-threatening condition defined by significantly impaired liver function): 5 people, 27.78%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 5 people, 27.78%
Nausea (feeling of having an urge to vomit): 5 people, 27.78%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 4 people, 22.22%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 22.22%
Cytolytic Hepatitis (dissolution or destruction of a liver cell): 4 people, 22.22%
Consciousness - Decreased: 4 people, 22.22%

What are the existing conditions these people have? *

Productive Cough: 4 people, 22.22%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 22.22%
Hepatic Neoplasm Malignant (liver cancer): 4 people, 22.22%
Hepatitis (inflammation of the liver): 4 people, 22.22%
High Blood Pressure: 4 people, 22.22%
Hepatitis B: 4 people, 22.22%
Pancreatitis (inflammation of pancreas): 2 people, 11.11%
Liver Disorder (liver diseases): 2 people, 11.11%
Gastric Ulcer (stomach ulcer): 2 people, 11.11%
Enlarged Prostate: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Zoladex and have Hepatic encephalopathy?

- Check whether Hepatic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoladex:

Zoladex (13,869 reports)

Browse all side effects of Zoladex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic encephalopathy:

Hepatic encephalopathy (917 drugs)

Browse all the conditions that are associated with Hepatic encephalopathy:

Hepatic encephalopathy (1,259 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on goserelin acetate (the active ingredients of Zoladex) and Zoladex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.