Zoledronic acid and Systemic inflammatory response syndrome - a phase IV clinical study of FDA data

Summary:

Systemic inflammatory response syndrome is reported as a side effect among people who take Zoledronic acid (zoledronic acid), especially for people who are male, 10-19 old, have been taking the drug for < 1 month also take Deflazacort, and have Spinal fracture.

The phase IV clinical study analyzes which people have Systemic inflammatory response syndrome when taking Zoledronic acid. It is created by eHealthMe based on reports of 28,440 people who have side effects when taking Zoledronic acid from the FDA, and is updated regularly.

What is Zoledronic acid?

Zoledronic acid has active ingredients of zoledronic acid. eHealthMe is studying from 28,485 Zoledronic acid users. Check the latest studies of Zoledronic acid.

What is Systemic inflammatory response syndrome?

Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection) is found to be associated with 575 drugs and 906 conditions by eHealthMe. Check the latest studies of Systemic inflammatory response syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

28,440 people reported to have side effects when taking Zoledronic acid.
Among them, 68 people (0.24%) have Systemic inflammatory response syndrome.

Could Zoledronic acid cause Systemic inflammatory response syndrome?

Among these 68 people:

How long have people been on Zoledronic acid when they have Systemic inflammatory response syndrome? *

What is the gender of people who have Systemic inflammatory response syndrome when taking Zoledronic acid? *

female: 13.56 %
male: 86.44 %

What is the age of people who have Systemic inflammatory response syndrome when taking Zoledronic acid? *

What are other drugs people take besides Zoledronic acid? *

What are other side effects people have besides Systemic inflammatory response syndrome? *

Arrhythmias (irregular heartbeat): 39 people, 57.35%
Fever: 35 people, 51.47%
Tachypnea: 33 people, 48.53%
Malaise (a feeling of general discomfort or uneasiness): 30 people, 44.12%
Blood Urine Present: 19 people, 27.94%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 19 people, 27.94%
Nausea And Vomiting: 19 people, 27.94%
Muscle Spasms (muscle contraction): 18 people, 26.47%
Diarrhea: 16 people, 23.53%
Nausea (feeling of having an urge to vomit): 13 people, 19.12%

What are the existing conditions these people have? *

Spinal Fracture (fracture in one of vertebrae): 29 people, 42.65%
Osteoporosis (bones weak and more likely to break): 17 people, 25.00%
Spinal Compression Fracture (fracture due to spinal compression on bone): 6 people, 8.82%
Osteoporotic Fracture (fracture due to weak bone): 4 people, 5.88%
Salivary Hypersecretion (excess saliva secretion): 3 people, 4.41%
Breast Cancer: 2 people, 2.94%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 1.47%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 1 person, 1.47%

* Approximation only. Some reports may have incomplete information.

Do you take Zoledronic acid and have Systemic inflammatory response syndrome?

- Check whether Systemic inflammatory response syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoledronic acid:

Zoledronic acid (28,485 reports)

Systemic inflammatory response syndrome treatments and more:

Systemic inflammatory response syndrome (5,055 reports)

How severe was Systemic inflammatory response syndrome and when was it recovered:

Systemic inflammatory response syndrome in Zoledronic acid

Expand to all the drugs that have ingredients of zoledronic acid:

Systemic inflammatory response syndrome and drugs with ingredients of zoledronic acid (150 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zoledronic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic inflammatory response syndrome:

Systemic inflammatory response syndrome (575 drugs)

Browse all the conditions that are associated with Systemic inflammatory response syndrome:

Systemic inflammatory response syndrome (906 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid (the active ingredients of Zoledronic acid) and Zoledronic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.