Zoledronic and Hyperparathyroidism - a phase IV clinical study of FDA data

Summary:

Hyperparathyroidism is reported as a side effect among people who take Zoledronic (zoledronic acid), especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years also take Acyclovir, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Hyperparathyroidism when taking Zoledronic. It is created by eHealthMe based on reports of 29,760 people who have side effects when taking Zoledronic from the FDA, and is updated regularly.

What is Zoledronic?

Zoledronic has active ingredients of zoledronic acid. eHealthMe is studying from 29,812 Zoledronic users. Check the latest studies of Zoledronic.

What is Hyperparathyroidism?

Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium) is found to be associated with 453 drugs and 445 conditions by eHealthMe. Check the latest studies of Hyperparathyroidism.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jun, 12, 2026

29,760 people reported to have side effects when taking Zoledronic.
Among them, 28 people (0.09%) have Hyperparathyroidism.

Could Zoledronic cause Hyperparathyroidism?

Among these 28 people:

How long have people been on Zoledronic when they have Hyperparathyroidism? *

What is the gender of people who have Hyperparathyroidism when taking Zoledronic? *

female: 80 %
male: 20 %

What is the age of people who have Hyperparathyroidism when taking Zoledronic? *

What are other drugs people take besides Zoledronic? *

Metformin: 4 people, 14.29%
Losartan: 4 people, 14.29%
Lamivudine: 4 people, 14.29%
Didanosine: 4 people, 14.29%
Acyclovir: 4 people, 14.29%
Tenofovir Disoproxil Fumarate: 3 people, 10.71%
Vitamin D3: 2 people, 7.14%
Forteo: 2 people, 7.14%
Diovan: 2 people, 7.14%
Bisoprolol Fumarate: 2 people, 7.14%

What are other side effects people have besides Hyperparathyroidism? *

Hypocalcaemia (levels of calcium in blood serum are abnormally low): 16 people, 57.14%
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood): 10 people, 35.71%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 9 people, 32.14%
Hyperthyroidism (over activity of the thyroid gland): 8 people, 28.57%
Hypernatraemia (an abnormally high plasma concentration of sodium ions): 8 people, 28.57%
Diabetes Insipidus - Nephrogenic (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 7 people, 25.00%
Rickets (softening of bones): 7 people, 25.00%
Fanconi Syndrome Acquired (self developed genetic disease of kidney damage due to defective transport system): 4 people, 14.29%
Lipids Abnormal: 4 people, 14.29%
Muscle Aches (muscle pain): 3 people, 10.71%

What are the existing conditions these people have? *

Hypercalcaemia (elevated calcium (ca+) level in the blood): 8 people, 28.57%
Bipolar Disorder (mood disorder): 8 people, 28.57%
Osteoporosis (bones weak and more likely to break): 6 people, 21.43%
Hiv Infection: 4 people, 14.29%
Metastases To Bone (cancer spreads to bone): 3 people, 10.71%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 3 people, 10.71%
Prostate Cancer Metastatic: 2 people, 7.14%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 2 people, 7.14%
High Blood Pressure: 2 people, 7.14%
Breast Cancer: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Zoledronic and have Hyperparathyroidism?

- Check whether Hyperparathyroidism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoledronic:

Zoledronic (29,812 reports)

Browse all side effects of Zoledronic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperparathyroidism:

Hyperparathyroidism (453 drugs)

Browse all the conditions that are associated with Hyperparathyroidism:

Hyperparathyroidism (445 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid (the active ingredients of Zoledronic) and Zoledronic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.