Zometa and Bipolar disorder - a phase IV clinical study of FDA data

Summary:

Bipolar disorder is reported as a side effect among people who take Zometa (zoledronic acid), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Alprazolam, and have Metastases to bone.

The phase IV clinical study analyzes which people have Bipolar disorder when taking Zometa. It is created by eHealthMe based on reports of 71,074 people who have side effects when taking Zometa from the FDA, and is updated regularly.

What is Zometa?

Zometa has active ingredients of zoledronic acid. It is often used in multiple myeloma. eHealthMe is studying from 71,434 Zometa users. Check the latest studies of Zometa.

What is Bipolar disorder?

Bipolar disorder (mood disorder) is found to be associated with 908 drugs and 1,231 conditions by eHealthMe. Check the latest studies of Bipolar disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

71,074 people reported to have side effects when taking Zometa.
Among them, 70 people (0.1%) have Bipolar disorder.

Among these 70 people:

How long have people been on Zometa when they have Bipolar disorder? *

What is the gender of people who have Bipolar disorder when taking Zometa? *

female: 76.56 %
male: 23.44 %

What is the age of people who have Bipolar disorder when taking Zometa? *

What are other drugs people take besides Zometa? *

What are other side effects people have besides Bipolar disorder? *

Pain: 61 people, 87.14%
Osteonecrosis Of Jaw (death of bone of jaw): 55 people, 78.57%
Stress And Anxiety: 55 people, 78.57%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 44 people, 62.86%
Depression: 43 people, 61.43%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 42 people, 60.00%
Anaemia (lack of blood): 42 people, 60.00%
Chest Pain: 40 people, 57.14%
Injury: 40 people, 57.14%
Back Pain: 40 people, 57.14%

What are the existing conditions these people have? *

Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 18 people, 25.71%
Metastases To Bone (cancer spreads to bone): 18 people, 25.71%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 13 people, 18.57%
Prostate Cancer: 8 people, 11.43%
Pain: 7 people, 10.00%
Movement - Uncontrolled Or Slow: 6 people, 8.57%
Abdominal Discomfort: 6 people, 8.57%
Osteoporosis (bones weak and more likely to break): 4 people, 5.71%
High Blood Pressure: 3 people, 4.29%
Hot Flush (sudden feelings of heat): 2 people, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Zometa and have Bipolar disorder?

- Check whether Bipolar disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zometa:

Zometa (71,434 reports)

Bipolar disorder treatments and more:

Bipolar disorder (109,430 reports)

Browse all side effects of Zometa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bipolar disorder:

Bipolar disorder (908 drugs)

Browse all the conditions that are associated with Bipolar disorder:

Bipolar disorder (1,231 conditions)

Related publications that referenced our studies

Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .
Ayano G, "Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics and Therapeutic Effects and Indications of Valproate: Review of Articles", Bipolar Disord, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid (the active ingredients of Zometa) and Zometa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.