Zometa and Ear barotrauma - a phase IV clinical study of FDA data

Summary:

We study 68,309 people who have side effects when taking Zometa. Ear barotrauma is found, especially among people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take Aredia and have Osteoporosis.

The phase IV clinical study analyzes which people take Zometa and have Ear barotrauma. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Jul, 16, 2023

68,309 people reported to have side effects when taking Zometa.
Among them, 169 people (0.25%) have Ear barotrauma.

What is Zometa?

Zometa has active ingredients of zoledronic acid. It is used in multiple myeloma. Currently, eHealthMe is studying from 70,203 Zometa users.

What is Ear barotrauma?

Ear barotrauma (discomfort and possible damage in the ear due to pressure differences between the inside and outside of the eardrum) is found to be associated with 928 drugs and 593 conditions by eHealthMe. Currently, we are studying 1,425 people who have Ear barotrauma.

Number of Zometa and Ear barotrauma reports submitted per year:

* Approximation only. Some reports may have incomplete information.

Do you take Zometa and have Ear barotrauma?

Check whether Ear barotrauma is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Zometa side effects by duration, gender and age:

Zometa side effects (70,203 reports)

Ear barotrauma treatments and more:

Ear barotrauma (1,425 reports)

Common drugs associated with Ear barotrauma:

Fosamax: 298 reports
Zofran: 174 reports
Zometa: 169 reports
Aspirin: 104 reports

All the drugs that are associated with Ear barotrauma:

Ear barotrauma (928 drugs)

Common conditions associated with Ear barotrauma:

Osteoporosis: 264 reports
High blood pressure: 112 reports

All the conditions that are associated with Ear barotrauma:

Ear barotrauma (593 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid (the active ingredients of Zometa) and Zometa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.