Zometa and Optic nerve cupping - a phase IV clinical study of FDA data

Summary:

Optic nerve cupping is reported as a side effect among people who take Zometa (zoledronic acid), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Aredia, and have Pain.

The phase IV clinical study analyzes which people have Optic nerve cupping when taking Zometa. It is created by eHealthMe based on reports of 71,074 people who have side effects when taking Zometa from the FDA, and is updated regularly.

What is Zometa?

Zometa has active ingredients of zoledronic acid. It is often used in multiple myeloma. eHealthMe is studying from 71,434 Zometa users. Check the latest studies of Zometa.

What is Optic nerve cupping?

Optic nerve cupping (the size of the depression in the middle of the nerve when viewed from the front of the eye) is found to be associated with 80 drugs and 110 conditions by eHealthMe. Check the latest studies of Optic nerve cupping.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

71,074 people reported to have side effects when taking Zometa.
Among them, 38 people (0.05%) have Optic nerve cupping.

Among these 38 people:

How long have people been on Zometa when they have Optic nerve cupping? *

What is the gender of people who have Optic nerve cupping when taking Zometa? *

female: 5.26 %
male: 94.74 %

What is the age of people who have Optic nerve cupping when taking Zometa? *

What are other drugs people take besides Zometa? *

What are other side effects people have besides Optic nerve cupping? *

Pain: 38 people, 100.00%
Stress And Anxiety: 38 people, 100.00%
General Physical Health Deterioration (weak health status): 37 people, 97.37%
Decreased Interest: 37 people, 97.37%
Vision Blurred: 37 people, 97.37%
Osteonecrosis Of Jaw (death of bone of jaw): 37 people, 97.37%
Plasmacytosis (presence of lots of plasma cells in bone or other tissues): 33 people, 86.84%
Bone Disorder: 30 people, 78.95%
Haematuria (presence of blood in urine): 29 people, 76.32%
Glaucoma (increased fluid pressure in the eye with vision loss): 28 people, 73.68%

What are the existing conditions these people have? *

Pain: 27 people, 71.05%
Prostatitis (inflammation of the prostate gland): 10 people, 26.32%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 2.63%
Prostate Cancer: 1 person, 2.63%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 2.63%
Metastasis (spreadable cancer to other organ from origin): 1 person, 2.63%
High Blood Pressure: 1 person, 2.63%
Asthma: 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Zometa and have Optic nerve cupping?

- Check whether Optic nerve cupping is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zometa:

Zometa (71,434 reports)

Browse all side effects of Zometa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Optic nerve cupping:

Optic nerve cupping (80 drugs)

Browse all the conditions that are associated with Optic nerve cupping:

Optic nerve cupping (110 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid (the active ingredients of Zometa) and Zometa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.