Zometa and Pyogenic granuloma - a phase IV clinical study of FDA data

Summary:

Pyogenic granuloma is reported as a side effect among people who take Zometa (zoledronic acid), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Aredia, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Pyogenic granuloma when taking Zometa. It is created by eHealthMe based on reports of 71,074 people who have side effects when taking Zometa from the FDA, and is updated regularly.

What is Zometa?

Zometa has active ingredients of zoledronic acid. It is often used in multiple myeloma. eHealthMe is studying from 71,434 Zometa users. Check the latest studies of Zometa.

What is Pyogenic granuloma?

Pyogenic granuloma (small, raised, red bumps on the skin) is found to be associated with 95 drugs and 236 conditions by eHealthMe. Check the latest studies of Pyogenic granuloma.

On Jul, 13, 2026

71,074 people reported to have side effects when taking Zometa.
Among them, 63 people (0.09%) have Pyogenic granuloma.

Among these 63 people:

How long have people been on Zometa when they have Pyogenic granuloma? *

What is the gender of people who have Pyogenic granuloma when taking Zometa? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Pyogenic granuloma when taking Zometa? *

What are other drugs people take besides Zometa? *

What are other side effects people have besides Pyogenic granuloma? *

Osteoarthritis (a joint disease caused by cartilage loss in a joint): 45 people, 71.43%
Osteonecrosis Of Jaw (death of bone of jaw): 43 people, 68.25%
Stress And Anxiety: 42 people, 66.67%
Pain: 38 people, 60.32%
Weakness: 36 people, 57.14%
Injury: 34 people, 53.97%
Osteomyelitis (infection of bone): 34 people, 53.97%
Neuropathy Peripheral (surface nerve damage): 33 people, 52.38%
Anaemia (lack of blood): 32 people, 50.79%
Back Pain: 28 people, 44.44%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 11.11%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 6 people, 9.52%
Thrombosis (formation of a blood clot inside a blood vessel): 6 people, 9.52%
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 6 people, 9.52%
Depression: 6 people, 9.52%
Pain: 6 people, 9.52%
Osteoporosis (bones weak and more likely to break): 6 people, 9.52%
Metastases To Bone (cancer spreads to bone): 5 people, 7.94%
Lipids Increased (excess lipid in body): 2 people, 3.17%
Neuropathy Peripheral (surface nerve damage): 2 people, 3.17%

* Approximation only. Some reports may have incomplete information.

Do you take Zometa and have Pyogenic granuloma?

- Check whether Pyogenic granuloma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zometa:

Zometa (71,434 reports)

Browse all side effects of Zometa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pyogenic granuloma:

Pyogenic granuloma (95 drugs)

Browse all the conditions that are associated with Pyogenic granuloma:

Pyogenic granuloma (236 conditions)

Related publications that referenced our studies

Ghalayani P, Hajisadeghi S, Babadi F, "Extragingival pyogenic granuloma associated with medication: Report of an unusual case", Dental research journal, 2014 Jan .
Yazdanian S, Parish LC, Lambert PC, Lambert WC, "Pyogenic granuloma: an enigma within a paradox or a solution in search of a problem", Skinmed, 2014 Jan .
Ghalayani P, Hajisadeghi S, Babadi F, "Extragingival pyogenic granuloma associated with medication: Report of an unusual case", Dental research journal, 2014 Jan .
Yazdanian S, Parish LC, Lambert PC, Lambert WC, "Pyogenic granuloma: an enigma within a paradox or a solution in search of a problem", Skinmed, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid (the active ingredients of Zometa) and Zometa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.