Zonegran and Agitation - a phase IV clinical study of FDA data

Summary:

Agitation is reported as a side effect among people who take Zonegran (zonisamide), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Keppra, and have Pain.

The phase IV clinical study analyzes which people have Agitation when taking Zonegran. It is created by eHealthMe based on reports of 5,875 people who have side effects when taking Zonegran from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Agitation?

Agitation (state of anxiety or nervous excitement) is found to be associated with 2,275 drugs and 3,311 conditions by eHealthMe. Check the latest studies of Agitation.

On Jul, 07, 2026

5,875 people reported to have side effects when taking Zonegran.
Among them, 130 people (2.21%) have Agitation.

Among these 130 people:

* Approximation only. Some reports may have incomplete information.

Do you take Zonegran and have Agitation?

- Check whether Agitation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zonegran:

Zonegran (6,211 reports)

Agitation treatments and more:

Agitation (142,107 reports)

How severe was Agitation and when was it recovered:

Agitation in Zonegran

Expand to all the drugs that have ingredients of zonisamide:

Agitation and drugs with ingredients of zonisamide (298 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zonegran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Agitation:

Agitation (2,275 drugs)

Browse all the conditions that are associated with Agitation:

Agitation (3,311 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on zonisamide (the active ingredients of Zonegran) and Zonegran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.