Zonegran and Bruxism - a phase IV clinical study of FDA data

Summary:

Bruxism is reported as a side effect among people who take Zonegran (zonisamide), especially for people who are male, 30-39 old, have been taking the drug for 6 - 12 months also take Nasonex, and have Pain.

The phase IV clinical study analyzes which people have Bruxism when taking Zonegran. It is created by eHealthMe based on reports of 5,875 people who have side effects when taking Zonegran from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Bruxism?

Bruxism (habitual grinding of the teeth, typically during sleep) is found to be associated with 589 drugs and 981 conditions by eHealthMe. Check the latest studies of Bruxism.

On Jul, 19, 2026

5,875 people reported to have side effects when taking Zonegran.
Among them, 13 people (0.22%) have Bruxism.

Among these 13 people:

How long have people been on Zonegran when they have Bruxism? *

What is the gender of people who have Bruxism when taking Zonegran? *

female: 45.45 %
male: 54.55 %

What is the age of people who have Bruxism when taking Zonegran? *

What are other drugs people take besides Zonegran? *

Nasonex: 6 people, 46.15%
Keppra: 4 people, 30.77%
Dilantin: 4 people, 30.77%
Zyrtec: 3 people, 23.08%
Lorazepam: 3 people, 23.08%
Lisinopril And Hydrochlorothiazide: 3 people, 23.08%
Mirapex: 3 people, 23.08%
Naproxen: 3 people, 23.08%
Lacosamide: 3 people, 23.08%
Ovcon-35: 3 people, 23.08%

What are other side effects people have besides Bruxism? *

Disturbance In Attention: 4 people, 30.77%
Drowsiness: 4 people, 30.77%
Stress And Anxiety: 4 people, 30.77%
Weight Increased: 3 people, 23.08%
Muscle Spasms (muscle contraction): 3 people, 23.08%
Dyskinesia (abnormality or impairment of voluntary movement): 3 people, 23.08%
Dysmorphism (difference of body structure that is suggestive of a congenital disorder): 3 people, 23.08%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 23.08%
Nasal Disorder (diseases of nose): 3 people, 23.08%
Ear Disorder: 3 people, 23.08%

What are the existing conditions these people have? *

Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 23.08%
Pain: 3 people, 23.08%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 15.38%
Stress And Anxiety: 1 person, 7.69%
Simple Partial Seizures (seizures which affect only a small region of the brain): 1 person, 7.69%
Nervousness: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Zonegran and have Bruxism?

- Check whether Bruxism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zonegran:

Zonegran (6,211 reports)

Bruxism treatments and more:

Bruxism (7,187 reports)

Browse all side effects of Zonegran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bruxism:

Bruxism (589 drugs)

Browse all the conditions that are associated with Bruxism:

Bruxism (981 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zonisamide (the active ingredients of Zonegran) and Zonegran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.