Zonegran and Coma - a phase IV clinical study of FDA data

Summary:

Coma is reported as a side effect among people who take Zonegran (zonisamide), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Keppra, and have Tuberous sclerosis.

The phase IV clinical study analyzes which people have Coma when taking Zonegran. It is created by eHealthMe based on reports of 5,875 people who have side effects when taking Zonegran from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Coma?

Coma (state of unconsciousness lasting more than six hours) is found to be associated with 2,818 drugs and 3,207 conditions by eHealthMe. Check the latest studies of Coma.

On Apr, 18, 2026

5,875 people reported to have side effects when taking Zonegran.
Among them, 50 people (0.85%) have Coma.

Among these 50 people:

How long have people been on Zonegran when they have Coma? *

What is the gender of people who have Coma when taking Zonegran? *

female: 63.04 %
male: 36.96 %

What is the age of people who have Coma when taking Zonegran? *

What are other drugs people take besides Zonegran? *

Keppra: 17 people, 34.00%
Lamictal: 16 people, 32.00%
Topamax: 11 people, 22.00%
Vimpat: 10 people, 20.00%
Valproate Sodium: 7 people, 14.00%
Tegretol: 6 people, 12.00%
Sabril: 6 people, 12.00%
Phenytoin: 5 people, 10.00%
Haldol: 5 people, 10.00%
Buprenorphine Hydrochloride: 4 people, 8.00%

What are other side effects people have besides Coma? *

Nausea And Vomiting: 12 people, 24.00%
Drowsiness: 9 people, 18.00%
Hypotension (abnormally low blood pressure): 8 people, 16.00%
Depression: 5 people, 10.00%
Suicide Attempt: 5 people, 10.00%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 5 people, 10.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 10.00%
Complex Partial Seizures (epileptic seizure): 4 people, 8.00%
Weakness: 4 people, 8.00%
Headache (pain in head): 4 people, 8.00%

What are the existing conditions these people have? *

Tuberous Sclerosis (a rare genetic disease that causes benign tumours to grow in the brain and other organs): 3 people, 6.00%
Pain: 2 people, 4.00%
Menstrual Disorder (disease of menstrual cycle): 2 people, 4.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 4.00%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 1 person, 2.00%
Idiopathic Generalised Epilepsy (epileptic disorders that are believed to have a strong underlying genetic basis): 1 person, 2.00%
Depression: 1 person, 2.00%
Blood Growth Hormone Decreased: 1 person, 2.00%
Astrocytoma, Low Grade (low grade tumour of the brain that originate in a particular kind of glial-cells): 1 person, 2.00%
Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells): 1 person, 2.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zonegran and have Coma?

- Check whether Coma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zonegran:

Zonegran (6,211 reports)

Coma treatments and more:

Coma (57,420 reports)

Browse all side effects of Zonegran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Coma:

Coma (2,818 drugs)

Browse all the conditions that are associated with Coma:

Coma (3,207 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zonisamide (the active ingredients of Zonegran) and Zonegran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.