Zonegran and Hyponatraemia aggravated - a phase IV clinical study of FDA data

Summary:

Hyponatraemia aggravated is reported as a side effect among people who take Zonegran (zonisamide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Trileptal, and have Pain.

The phase IV clinical study analyzes which people have Hyponatraemia aggravated when taking Zonegran. It is created by eHealthMe based on reports of 5,875 people who have side effects when taking Zonegran from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Hyponatraemia aggravated?

Hyponatraemia aggravated (abnormally low concentrations of sodium ions in the circulating blood) is found to be associated with 1,506 drugs and 543 conditions by eHealthMe. Check the latest studies of Hyponatraemia aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

5,875 people reported to have side effects when taking Zonegran.
Among them, 36 people (0.61%) have Hyponatraemia aggravated.

Could Zonegran cause Hyponatraemia aggravated?

Among these 36 people:

How long have people been on Zonegran when they have Hyponatraemia aggravated? *

What is the gender of people who have Hyponatraemia aggravated when taking Zonegran? *

female: 69.7 %
male: 30.3 %

What is the age of people who have Hyponatraemia aggravated when taking Zonegran? *

What are other drugs people take besides Zonegran? *

What are other side effects people have besides Hyponatraemia aggravated? *

Headache (pain in head): 10 people, 27.78%
General Physical Health Deterioration (weak health status): 6 people, 16.67%
Head Injury: 4 people, 11.11%
Overdose: 4 people, 11.11%
Chest Pain: 4 people, 11.11%
Urinary Tract Infection: 3 people, 8.33%
Movement - Uncoordinated: 3 people, 8.33%
Confusion: 3 people, 8.33%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 8.33%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 3 people, 8.33%

What are the existing conditions these people have? *

Partial Seizures (seizures which affect only a part of the brain at onset): 7 people, 19.44%
Pain: 7 people, 19.44%
Infection: 6 people, 16.67%
Abnormal Behavior: 3 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.56%
Depression: 2 people, 5.56%
High Blood Cholesterol: 2 people, 5.56%
High Blood Pressure: 2 people, 5.56%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 2.78%
Memory Loss: 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Zonegran and have Hyponatraemia aggravated?

- Check whether Hyponatraemia aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zonegran:

Zonegran (6,211 reports)

Browse all side effects of Zonegran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatraemia aggravated:

Hyponatraemia aggravated (1,507 drugs)

Browse all the conditions that are associated with Hyponatraemia aggravated:

Hyponatraemia aggravated (543 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zonisamide (the active ingredients of Zonegran) and Zonegran (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.