Zonisamide and Bone pain - a phase IV clinical study of FDA data

Summary:

Bone pain is reported as a side effect among people who take Zonisamide (zonisamide), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Cymbalta, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Bone pain when taking Zonisamide. It is created by eHealthMe based on reports of 11,045 people who have side effects when taking Zonisamide from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Bone pain?

Bone pain is found to be associated with 1,812 drugs and 1,778 conditions by eHealthMe. Check the latest studies of Bone pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

11,045 people reported to have side effects when taking Zonisamide.
Among them, 21 people (0.19%) have Bone pain.

Among these 21 people:

How long have people been on Zonisamide when they have Bone pain? *

What is the gender of people who have Bone pain when taking Zonisamide? *

female: 83.33 %
male: 16.67 %

What is the age of people who have Bone pain when taking Zonisamide? *

What are other drugs people take besides Zonisamide? *

What are other side effects people have besides Bone pain? *

Headache (pain in head): 15 people, 71.43%
Fatigue (feeling of tiredness): 12 people, 57.14%
Weakness: 10 people, 47.62%
Muscle Aches (muscle pain): 10 people, 47.62%
Nausea (feeling of having an urge to vomit): 10 people, 47.62%
Pain In Extremity: 8 people, 38.10%
Muscle Spasms (muscle contraction): 6 people, 28.57%
Malaise (a feeling of general discomfort or uneasiness): 6 people, 28.57%
Pain: 6 people, 28.57%
Fall: 6 people, 28.57%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 28.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 19.05%
Neuropathy Peripheral (surface nerve damage): 3 people, 14.29%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 14.29%
Pain: 3 people, 14.29%
Heart Rate Decreased: 2 people, 9.52%
High Blood Cholesterol: 2 people, 9.52%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 9.52%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 9.52%
Insomnia (sleeplessness): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Zonisamide and have Bone pain?

- Check whether Bone pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zonisamide:

Zonisamide (11,445 reports)

Bone pain treatments and more:

Bone pain (76,561 reports)

Browse all side effects of Zonisamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone pain:

Bone pain (1,812 drugs)

Browse all the conditions that are associated with Bone pain:

Bone pain (1,778 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zonisamide (the active ingredients of Zonisamide) and Zonisamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.