Zonisamide and Cardiac arrest - a phase IV clinical study of FDA data

Summary:

Cardiac arrest is reported as a side effect among people who take Zonisamide (zonisamide), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Melatonin, and have General anaesthesia.

The phase IV clinical study analyzes which people have Cardiac arrest when taking Zonisamide. It is created by eHealthMe based on reports of 11,045 people who have side effects when taking Zonisamide from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Cardiac arrest?

Cardiac arrest is found to be associated with 2,229 drugs and 2,513 conditions by eHealthMe. Check the latest studies of Cardiac arrest.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

11,045 people reported to have side effects when taking Zonisamide.
Among them, 65 people (0.59%) have Cardiac arrest.

Among these 65 people:

How long have people been on Zonisamide when they have Cardiac arrest? *

What is the gender of people who have Cardiac arrest when taking Zonisamide? *

female: 40.35 %
male: 59.65 %

What is the age of people who have Cardiac arrest when taking Zonisamide? *

What are other drugs people take besides Zonisamide? *

What are other side effects people have besides Cardiac arrest? *

Bradycardia (abnormally slow heart action): 21 people, 32.31%
Hypotension (abnormally low blood pressure): 20 people, 30.77%
Overdose: 18 people, 27.69%
Breathing - Slowed Or Stopped: 13 people, 20.00%
Pulseless Electrical Activity: 11 people, 16.92%
Sinus Bradycardia (an unusually slow heartbeat due to heart disease): 8 people, 12.31%
Acute Kidney Failure: 5 people, 7.69%
Pericardial Effusion (fluid around the heart): 5 people, 7.69%
Drug Rash With Eosinophilia And Systemic Symptoms (adverse drug reactions with rash): 4 people, 6.15%
Drop Attacks (sudden spontaneous falls while standing or walking): 3 people, 4.62%

What are the existing conditions these people have? *

General Anaesthesia: 14 people, 21.54%
Muscle Function Loss: 13 people, 20.00%
Abnormal Behavior: 11 people, 16.92%
Temporal Lobe Epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe): 5 people, 7.69%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 6.15%
Respiratory Tract Infection: 4 people, 6.15%
Insomnia (sleeplessness): 2 people, 3.08%
High Blood Pressure: 2 people, 3.08%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 3.08%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 1 person, 1.54%

* Approximation only. Some reports may have incomplete information.

Do you take Zonisamide and have Cardiac arrest?

- Check whether Cardiac arrest is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zonisamide:

Zonisamide (11,445 reports)

Cardiac arrest treatments and more:

Cardiac arrest (101,931 reports)

Browse all side effects of Zonisamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cardiac arrest:

Cardiac arrest (2,229 drugs)

Browse all the conditions that are associated with Cardiac arrest:

Cardiac arrest (2,513 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zonisamide (the active ingredients of Zonisamide) and Zonisamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.