Zonisamide and Drooling - a phase IV clinical study of FDA data

Summary:

Drooling is reported as a side effect among people who take Zonisamide (zonisamide), especially for people who are female, 50-59 old, also take Keppra, and have Agitation.

The phase IV clinical study analyzes which people have Drooling when taking Zonisamide. It is created by eHealthMe based on reports of 11,045 people who have side effects when taking Zonisamide from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Drooling?

Drooling (drop saliva uncontrollably from the mouth) is found to be associated with 497 drugs and 941 conditions by eHealthMe. Check the latest studies of Drooling.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

11,045 people reported to have side effects when taking Zonisamide.
Among them, 35 people (0.32%) have Drooling.

Among these 35 people:

What is the gender of people who have Drooling when taking Zonisamide? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Drooling when taking Zonisamide? *

What are other drugs people take besides Zonisamide? *

What are other side effects people have besides Drooling? *

Drowsiness: 8 people, 22.86%
Tremor (trembling or shaking movements in one or more parts of your body): 7 people, 20.00%
Constipation: 6 people, 17.14%
Nausea And Vomiting: 6 people, 17.14%
Feeling Abnormal: 5 people, 14.29%
Fatigue (feeling of tiredness): 5 people, 14.29%
Drug Ineffective: 3 people, 8.57%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 8.57%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 3 people, 8.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.57%

What are the existing conditions these people have? *

Agitation (state of anxiety or nervous excitement): 5 people, 14.29%
Hypersensitivity: 4 people, 11.43%
Depression: 2 people, 5.71%
Myoclonic Epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs): 2 people, 5.71%
Hidradenitis (chronic disease of a type of sweat gland): 2 people, 5.71%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 2 people, 5.71%
Immune System Disorder: 1 person, 2.86%
Asthma: 1 person, 2.86%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 2.86%
Bipolar Disorder (mood disorder): 1 person, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Zonisamide and have Drooling?

- Check whether Drooling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zonisamide:

Zonisamide (11,445 reports)

Drooling treatments and more:

Drooling (8,115 reports)

Browse all side effects of Zonisamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Drooling:

Drooling (497 drugs)

Browse all the conditions that are associated with Drooling:

Drooling (941 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zonisamide (the active ingredients of Zonisamide) and Zonisamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.