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Zonisamide and Hyponatremia - a phase IV clinical study of FDA data

Summary:

Hyponatremia is reported as a side effect among people who take Zonisamide (zonisamide), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Clobazam, and have Pain.

The phase IV clinical study analyzes which people have Hyponatremia when taking Zonisamide. It is created by eHealthMe based on reports of 11,045 people who have side effects when taking Zonisamide from the FDA, and is updated regularly.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 1,938 drugs and 2,272 conditions by eHealthMe. Check the latest studies of Hyponatremia.

On Jul, 06, 2026

11,045 people reported to have side effects when taking Zonisamide.
Among them, 37 people (0.33%) have Hyponatremia.

Could Zonisamide cause Hyponatremia?

Among these 37 people:

How long have people been on Zonisamide when they have Hyponatremia? *

  • < 1 month: 20 %
  • 1 - 6 months: 80 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyponatremia when taking Zonisamide? *

  • female: 43.75 %
  • male: 56.25 %

What is the age of people who have Hyponatremia when taking Zonisamide? *

  • 0-1: 10.0 %
  • 2-9: 0.0 %
  • 10-19: 3.33 %
  • 20-29: 6.67 %
  • 30-39: 0.0 %
  • 40-49: 20.0 %
  • 50-59: 16.67 %
  • 60+: 43.33 %

What are other drugs people take besides Zonisamide? *

  1. Clobazam: 12 people, 32.43%
  2. Lacosamide: 10 people, 27.03%
  3. Perampanel: 9 people, 24.32%
  4. Oxcarbazepine: 9 people, 24.32%
  5. Phenytoin: 9 people, 24.32%
  6. Gabapentin: 8 people, 21.62%
  7. Lamotrigine: 8 people, 21.62%
  8. Valproic Acid: 7 people, 18.92%
  9. Levetiracetam: 7 people, 18.92%
  10. Midazolam: 7 people, 18.92%

What are other side effects people have besides Hyponatremia? *

  1. Gait Disturbance: 9 people, 24.32%
  2. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 9 people, 24.32%
  3. Hypersensitivity: 8 people, 21.62%
  4. Dizziness: 8 people, 21.62%
  5. Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 8 people, 21.62%
  6. Depressed Mood: 7 people, 18.92%
  7. Postictal Paralysis: 7 people, 18.92%
  8. Gingival Disorder (gum disease): 7 people, 18.92%
  9. Overdose: 7 people, 18.92%
  10. Weight Increased: 7 people, 18.92%

What are the existing conditions these people have? *

  1. Diabetes Insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 3 people, 8.11%
  2. High Blood Pressure: 3 people, 8.11%
  3. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 8.11%
  4. Infantile Spasms: 3 people, 8.11%
  5. Lung Adenocarcinoma (a form of non-small cell lung cancer): 3 people, 8.11%
  6. Pain: 3 people, 8.11%
  7. Tonic Convulsion (the person will quickly lose consciousness and the skeletal muscles will suddenly tense, often causing the extremities to be pulled towards the body or rigidly pushed away from it): 2 people, 5.41%
  8. High Blood Cholesterol: 2 people, 5.41%
  9. Hypernatraemia (an abnormally high plasma concentration of sodium ions): 2 people, 5.41%
  10. Itching: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Zonisamide and have Hyponatremia?

- Check whether Hyponatremia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zonisamide:

Hyponatremia treatments and more:

How severe was Hyponatremia and when was it recovered:

Expand to all the drugs that have ingredients of zonisamide:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zonisamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatremia:

Browse all the conditions that are associated with Hyponatremia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on zonisamide (the active ingredients of Zonisamide) and Zonisamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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