Zopiclone and Acidosis - a phase IV clinical study of FDA data

Summary:

Acidosis is reported as a side effect among people who take Zopiclone (eszopiclone), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Mirtazapine, and have Schizophrenia.

The phase IV clinical study analyzes which people have Acidosis when taking Zopiclone. It is created by eHealthMe based on reports of 52,551 people who have side effects when taking Zopiclone from the FDA, and is updated regularly.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 54,330 Zopiclone users. Check the latest studies of Zopiclone.

What is Acidosis?

Acidosis (build-up of carbon dioxide in the blood) is found to be associated with 868 drugs and 1,015 conditions by eHealthMe. Check the latest studies of Acidosis.

On Jul, 13, 2026

52,551 people reported to have side effects when taking Zopiclone.
Among them, 63 people (0.12%) have Acidosis.

Among these 63 people:

How long have people been on Zopiclone when they have Acidosis? *

What is the gender of people who have Acidosis when taking Zopiclone? *

female: 65.52 %
male: 34.48 %

What is the age of people who have Acidosis when taking Zopiclone? *

What are other drugs people take besides Zopiclone? *

Mirtazapine: 17 people, 26.98%
Citalopram Hydrobromide: 15 people, 23.81%
Fluoxetine: 14 people, 22.22%
Diclofenac: 11 people, 17.46%
Metoclopramide: 9 people, 14.29%
Linezolid: 8 people, 12.70%
Azithromycin: 8 people, 12.70%
Lamprene: 8 people, 12.70%
Tranxene: 6 people, 9.52%
Diclofenac Sodium: 6 people, 9.52%

What are other side effects people have besides Acidosis? *

Hypotension (abnormally low blood pressure): 33 people, 52.38%
Overdose: 22 people, 34.92%
Consciousness - Decreased: 21 people, 33.33%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 20 people, 31.75%
Cardiac Arrest: 20 people, 31.75%
Hyperkalemia (damage to or disease of the kidney): 19 people, 30.16%
Arrhythmias (irregular heartbeat): 18 people, 28.57%
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions): 17 people, 26.98%
Ventricular Fibrillation (abnormally irregular heart rhythm): 17 people, 26.98%
Acute Pulmonary Oedema (sudden deposit of fluid in the lung)): 17 people, 26.98%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 10 people, 15.87%
Nausea (feeling of having an urge to vomit): 9 people, 14.29%
Atypical Mycobacterial Infection (infections caused by several types of mycobacterium similar to the germ that causes tuberculosis): 8 people, 12.70%
Poisoning Deliberate: 5 people, 7.94%
Stress And Anxiety: 3 people, 4.76%
Immune Tolerance Induction: 3 people, 4.76%
Ill-Defined Disorder: 2 people, 3.17%
Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 1.59%
Overdose: 1 person, 1.59%
Muscle Rigidity (muscle stiffness): 1 person, 1.59%

* Approximation only. Some reports may have incomplete information.

Do you take Zopiclone and have Acidosis?

- Check whether Acidosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zopiclone:

Zopiclone (54,330 reports)

Acidosis treatments and more:

Acidosis (9,686 reports)

Browse all side effects of Zopiclone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acidosis:

Acidosis (868 drugs)

Browse all the conditions that are associated with Acidosis:

Acidosis (1,015 conditions)

Related publications that referenced our studies

Lai SW, Lai HC, Lin CL, Liao KF, "Zopiclone use associated with increased risk of acute pancreatitis: a case–control study in Taiwan", International journal of clinical practice, 2015 Nov .
Lai SW, Lai HC, Lin CL, Liao KF, "Zopiclone use associated with increased risk of acute pancreatitis: a case–control study in Taiwan", International journal of clinical practice, 2015 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on eszopiclone (the active ingredients of Zopiclone) and Zopiclone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.