Zopiclone and Nephrotic syndrome - a phase IV clinical study of FDA data

Summary:

Nephrotic syndrome is reported as a side effect among people who take Zopiclone (eszopiclone), especially for people who are male, 60+ old, also take Spironolactone, and have Diarrhea.

The phase IV clinical study analyzes which people have Nephrotic syndrome when taking Zopiclone. It is created by eHealthMe based on reports of 52,551 people who have side effects when taking Zopiclone from the FDA, and is updated regularly.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 54,330 Zopiclone users. Check the latest studies of Zopiclone.

What is Nephrotic syndrome?

Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema) is found to be associated with 627 drugs and 1,070 conditions by eHealthMe. Check the latest studies of Nephrotic syndrome.

On Jul, 17, 2026

52,551 people reported to have side effects when taking Zopiclone.
Among them, 21 people (0.04%) have Nephrotic syndrome.

Could Zopiclone cause Nephrotic syndrome?

Among these 21 people:

What is the gender of people who have Nephrotic syndrome when taking Zopiclone? *

female: 23.81 %
male: 76.19 %

What is the age of people who have Nephrotic syndrome when taking Zopiclone? *

What are other drugs people take besides Zopiclone? *

What are other side effects people have besides Nephrotic syndrome? *

C-Reactive Protein Increased: 2 people, 9.52%
Acute Kidney Failure: 2 people, 9.52%
Glomerular Filtration Rate Decreased: 2 people, 9.52%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 2 people, 9.52%
Renal Impairment (severely reduced kidney function): 2 people, 9.52%
Oedema Peripheral (superficial swelling): 2 people, 9.52%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 9.52%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 9.52%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 4.76%
Chest Pain: 1 person, 4.76%

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 47.62%
Diabetes: 10 people, 47.62%
Diarrhea: 10 people, 47.62%
Oropharyngeal Pain: 8 people, 38.10%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 8 people, 38.10%
Bladder Outlet Obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded): 8 people, 38.10%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 8 people, 38.10%
Headache (pain in head): 8 people, 38.10%
Hepatic Neoplasm Malignant (liver cancer): 8 people, 38.10%
Abdominal Distension: 8 people, 38.10%

* Approximation only. Some reports may have incomplete information.

Do you take Zopiclone and have Nephrotic syndrome?

- Check whether Nephrotic syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zopiclone:

Zopiclone (54,330 reports)

Browse all side effects of Zopiclone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nephrotic syndrome:

Nephrotic syndrome (627 drugs)

Browse all the conditions that are associated with Nephrotic syndrome:

Nephrotic syndrome (1,070 conditions)

Related publications that referenced our studies

Lai SW, Lai HC, Lin CL, Liao KF, "Zopiclone use associated with increased risk of acute pancreatitis: a case–control study in Taiwan", International journal of clinical practice, 2015 Nov .
Lai SW, Lai HC, Lin CL, Liao KF, "Zopiclone use associated with increased risk of acute pancreatitis: a case–control study in Taiwan", International journal of clinical practice, 2015 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on eszopiclone (the active ingredients of Zopiclone) and Zopiclone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.