Zoryve and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Zoryve (rofumilast), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Bryhali, and have Psoriasis.

The phase IV clinical study analyzes which people have Headache when taking Zoryve. It is created by eHealthMe based on reports of 143 people who have side effects when taking Zoryve from the FDA, and is updated regularly.

What is Zoryve?

Zoryve has active ingredients of rofumilast. eHealthMe is studying from 143 Zoryve users. Check the latest studies of Zoryve.

What is Headache?

Headache (pain in head) is found to be associated with 3,756 drugs and 5,776 conditions by eHealthMe. Check the latest studies of Headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

143 people reported to have side effects when taking Zoryve.
Among them, 21 people (14.69%) have Headache.

Among these 21 people:

How long have people been on Zoryve when they have Headache? *

What is the gender of people who have Headache when taking Zoryve? *

female: 44.44 %
male: 55.56 %

What is the age of people who have Headache when taking Zoryve? *

What are other drugs people take besides Zoryve? *

What are other side effects people have besides Headache? *

Diarrhea: 6 people, 28.57%
Nausea (feeling of having an urge to vomit): 5 people, 23.81%
Dizziness: 4 people, 19.05%
Insomnia (sleeplessness): 4 people, 19.05%
Fatigue (feeling of tiredness): 3 people, 14.29%
Weakness: 3 people, 14.29%
Weight Decreased: 2 people, 9.52%
Nausea And Vomiting: 2 people, 9.52%
Chest Pain: 2 people, 9.52%
Dyspnea (difficult or laboured breathing): 2 people, 9.52%

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 15 people, 71.43%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 19.05%
Rashes (redness): 2 people, 9.52%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 1 person, 4.76%
Rosacea (a skin condition that causes facial redness): 1 person, 4.76%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Zoryve and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoryve:

Zoryve (143 reports)

Headache treatments and more:

Headache (756,645 reports)

Browse all side effects of Zoryve:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,756 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,776 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on rofumilast (the active ingredients of Zoryve) and Zoryve (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.