Zosyn and Acute hepatic failure - a phase IV clinical study of FDA data

Summary:

Acute hepatic failure is reported as a side effect among people who take Zosyn (piperacillin sodium; tazobactam sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vancomycin, and have High blood pressure.

The phase IV clinical study analyzes which people have Acute hepatic failure when taking Zosyn. It is created by eHealthMe based on reports of 10,175 people who have side effects when taking Zosyn from the FDA, and is updated regularly.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

What is Acute hepatic failure?

Acute hepatic failure is found to be associated with 710 drugs and 1,184 conditions by eHealthMe. Check the latest studies of Acute hepatic failure.

On Aug, 02, 2026

10,175 people reported to have side effects when taking Zosyn.
Among them, 16 people (0.16%) have Acute hepatic failure.

Could Zosyn cause Acute hepatic failure?

Among these 16 people:

How long have people been on Zosyn when they have Acute hepatic failure? *

What is the gender of people who have Acute hepatic failure when taking Zosyn? *

female: 60 %
male: 40 %

What is the age of people who have Acute hepatic failure when taking Zosyn? *

What are other drugs people take besides Zosyn? *

What are other side effects people have besides Acute hepatic failure? *

Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 25.00%
Acute Kidney Failure: 4 people, 25.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 18.75%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 3 people, 18.75%
Anaemia (lack of blood): 3 people, 18.75%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 2 people, 12.50%
Peripheral Ischaemia (impaired circulation to an extremity): 2 people, 12.50%
Post Procedural Haemorrhage (post procedural bleeding): 2 people, 12.50%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 2 people, 12.50%
Cardiogenic Shock (inadequate circulation of blood): 2 people, 12.50%

What are the existing conditions these people have? *

Hypocholesterolaemia (presence of abnormally small amounts of cholesterol in the circulating blood): 2 people, 12.50%
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking): 2 people, 12.50%
High Blood Pressure: 2 people, 12.50%
Vaginal Bleeding: 1 person, 6.25%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 6.25%
Bacterial Infection: 1 person, 6.25%
Cardiac Failure Congestive: 1 person, 6.25%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 1 person, 6.25%
Constipation: 1 person, 6.25%
Endometritis (inflammation of the endometrium): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Zosyn and have Acute hepatic failure?

- Check whether Acute hepatic failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zosyn:

Zosyn (10,236 reports)

Acute hepatic failure treatments and more:

Acute hepatic failure (13,839 reports)

How severe was Acute hepatic failure and when was it recovered:

Acute hepatic failure in Zosyn

Expand to all the drugs that have ingredients of piperacillin sodium; tazobactam sodium:

Acute hepatic failure and drugs with ingredients of piperacillin sodium; tazobactam sodium

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zosyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute hepatic failure:

Acute hepatic failure (710 drugs)

Browse all the conditions that are associated with Acute hepatic failure:

Acute hepatic failure (1,184 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on piperacillin sodium; tazobactam sodium (the active ingredients of Zosyn) and Zosyn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.