Zyban and Homicidal ideation - a phase IV clinical study of FDA data

Summary:

Homicidal ideation is reported as a side effect among people who take Zyban (bupropion hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Cytomel, and have Agitation.

The phase IV clinical study analyzes which people have Homicidal ideation when taking Zyban. It is created by eHealthMe based on reports of 7,776 people who have side effects when taking Zyban from the FDA, and is updated regularly.

What is Zyban?

Zyban has active ingredients of bupropion hydrochloride. It is often used in quit smoking. eHealthMe is studying from 8,029 Zyban users. Check the latest studies of Zyban.

What is Homicidal ideation?

Homicidal ideation (thoughts about human killing another human) is found to be associated with 361 drugs and 523 conditions by eHealthMe. Check the latest studies of Homicidal ideation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

7,776 people reported to have side effects when taking Zyban.
Among them, 21 people (0.27%) have Homicidal ideation.

Among these 21 people:

How long have people been on Zyban when they have Homicidal ideation? *

What is the gender of people who have Homicidal ideation when taking Zyban? *

female: 60 %
male: 40 %

What is the age of people who have Homicidal ideation when taking Zyban? *

What are other drugs people take besides Zyban? *

What are other side effects people have besides Homicidal ideation? *

Insomnia (sleeplessness): 9 people, 42.86%
Irritability: 7 people, 33.33%
Stress And Anxiety: 6 people, 28.57%
Anger: 6 people, 28.57%
Headache (pain in head): 5 people, 23.81%
Suicidal Ideation: 5 people, 23.81%
Mood Swings (an extreme or rapid change in mood): 5 people, 23.81%
Fatigue (feeling of tiredness): 4 people, 19.05%
Nausea (feeling of having an urge to vomit): 2 people, 9.52%
Libido Decreased (loss of interest in sex): 2 people, 9.52%

What are the existing conditions these people have? *

Type 2 Diabetes: 1 person, 4.76%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 4.76%
Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 1 person, 4.76%
Agitation (state of anxiety or nervous excitement): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Zyban and have Homicidal ideation?

- Check whether Homicidal ideation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zyban:

Zyban (8,029 reports)

Browse all side effects of Zyban:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Homicidal ideation:

Homicidal ideation (361 drugs)

Browse all the conditions that are associated with Homicidal ideation:

Homicidal ideation (523 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Zyban) and Zyban (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.