Zyclara and Joint pain - a phase IV clinical study of FDA data

Summary:

Joint pain is reported as a side effect among people who take Zyclara (imiquimod), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Erivedge, and have Actinic keratosis.

The phase IV clinical study analyzes which people have Joint pain when taking Zyclara. It is created by eHealthMe based on reports of 449 people who have side effects when taking Zyclara from the FDA, and is updated regularly.

What is Zyclara?

Zyclara has active ingredients of imiquimod. eHealthMe is studying from 462 Zyclara users. Check the latest studies of Zyclara.

What is Joint pain?

Joint pain is found to be associated with 3,328 drugs and 5,212 conditions by eHealthMe. Check the latest studies of Joint pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 14, 2026

449 people reported to have side effects when taking Zyclara.
Among them, 19 people (4.23%) have Joint pain.

Among these 19 people:

How long have people been on Zyclara when they have Joint pain? *

What is the gender of people who have Joint pain when taking Zyclara? *

female: 36.84 %
male: 63.16 %

What is the age of people who have Joint pain when taking Zyclara? *

What are other drugs people take besides Zyclara? *

Zyrtec: 1 person, 5.26%
Vitamin D: 1 person, 5.26%
Vitamin C: 1 person, 5.26%
Vesicare: 1 person, 5.26%
Tamsulosin: 1 person, 5.26%
Pantoprazole: 1 person, 5.26%
Multivitamin: 1 person, 5.26%
Magnesium: 1 person, 5.26%
Estradiol And Progesterone: 1 person, 5.26%
Erivedge: 1 person, 5.26%

What are other side effects people have besides Joint pain? *

Influenza Like Illness: 6 people, 31.58%
Dizziness: 5 people, 26.32%
Pain: 5 people, 26.32%
Headache (pain in head): 4 people, 21.05%
Weakness: 4 people, 21.05%
Fever: 4 people, 21.05%
Muscle Aches (muscle pain): 4 people, 21.05%
Rashes (redness): 3 people, 15.79%
Chills (felling of cold): 3 people, 15.79%
Abdominal Pain Upper: 2 people, 10.53%

What are the existing conditions these people have? *

Actinic Keratosis (skin disease due to sun exposure): 7 people, 36.84%
Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 3 people, 15.79%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 5.26%
Squamous Cell Carcinoma (a cancer of a kind of epithelial cell): 1 person, 5.26%
Skin Cancer: 1 person, 5.26%
Prostatic Disorder: 1 person, 5.26%
Precancerous Skin Lesion: 1 person, 5.26%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 1 person, 5.26%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 1 person, 5.26%
Neoplasm Malignant (cancer tumour): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Zyclara and have Joint pain?

- Check whether Joint pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zyclara:

Zyclara (462 reports)

Joint pain treatments and more:

Joint pain (542,935 reports)

Browse all side effects of Zyclara:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint pain:

Joint pain (3,328 drugs)

Browse all the conditions that are associated with Joint pain:

Joint pain (5,212 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on imiquimod (the active ingredients of Zyclara) and Zyclara (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.