Zyloprim and Fluid overload - a phase IV clinical study of FDA data

Summary:

Fluid overload is reported as a side effect among people who take Zyloprim (allopurinol), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Fluid overload when taking Zyloprim. It is created by eHealthMe based on reports of 5,556 people who have side effects when taking Zyloprim from the FDA, and is updated regularly.

What is Zyloprim?

Zyloprim has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 5,638 Zyloprim users. Check the latest studies of Zyloprim.

What is Fluid overload?

Fluid overload (too much fluid in the blood) is found to be associated with 1,025 drugs and 1,051 conditions by eHealthMe. Check the latest studies of Fluid overload.

On Aug, 03, 2026

5,556 people reported to have side effects when taking Zyloprim.
Among them, 47 people (0.85%) have Fluid overload.

Among these 47 people:

How long have people been on Zyloprim when they have Fluid overload? *

What is the gender of people who have Fluid overload when taking Zyloprim? *

female: 45.65 %
male: 54.35 %

What is the age of people who have Fluid overload when taking Zyloprim? *

What are other drugs people take besides Zyloprim? *

What are other side effects people have besides Fluid overload? *

Dyspnea (difficult or laboured breathing): 25 people, 53.19%
Pleural Effusion (water on the lungs): 18 people, 38.30%
Atelectasis (partial or complete collapse of the lung): 16 people, 34.04%
Hypotension (abnormally low blood pressure): 15 people, 31.91%
Oedema Peripheral (superficial swelling): 15 people, 31.91%
Pneumonia: 15 people, 31.91%
Fatigue (feeling of tiredness): 14 people, 29.79%
Diarrhea: 14 people, 29.79%
Cardiac Failure Congestive: 14 people, 29.79%
Blood Creatinine Increased: 13 people, 27.66%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 12 people, 25.53%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 7 people, 14.89%
Pain: 7 people, 14.89%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 6 people, 12.77%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 8.51%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 6.38%
Nasal Dryness (dry nose): 3 people, 6.38%
Affective Disorder (mental disorder): 3 people, 6.38%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 6.38%
Type 2 Diabetes: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

Do you take Zyloprim and have Fluid overload?

- Check whether Fluid overload is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zyloprim:

Zyloprim (5,638 reports)

Fluid overload treatments and more:

Fluid overload (20,385 reports)

Browse all side effects of Zyloprim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid overload:

Fluid overload (1,025 drugs)

Browse all the conditions that are associated with Fluid overload:

Fluid overload (1,051 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on allopurinol (the active ingredients of Zyloprim) and Zyloprim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.