Zyprexa and Intermittent explosive disorder - a phase IV clinical study of FDA data

Summary:

Intermittent explosive disorder is reported as a side effect among people who take Zyprexa (olanzapine), especially for people who are male, 40-49 old, have been taking the drug for 1 - 2 years also take Seroquel, and have Affective disorder.

The phase IV clinical study analyzes which people have Intermittent explosive disorder when taking Zyprexa. It is created by eHealthMe based on reports of 63,412 people who have side effects when taking Zyprexa from the FDA, and is updated regularly.

What is Zyprexa?

Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.

What is Intermittent explosive disorder?

Intermittent explosive disorder (behavioural disorder characterized by extreme expressions of anger) is found to be associated with 12 drugs and 111 conditions by eHealthMe. Check the latest studies of Intermittent explosive disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

63,412 people reported to have side effects when taking Zyprexa.
Among them, 12 people (0.02%) have Intermittent explosive disorder.

Could Zyprexa cause Intermittent explosive disorder?

Among these 12 people:

How long have people been on Zyprexa when they have Intermittent explosive disorder? *

What is the gender of people who have Intermittent explosive disorder when taking Zyprexa? *

female: 8.33 %
male: 91.67 %

What is the age of people who have Intermittent explosive disorder when taking Zyprexa? *

What are other drugs people take besides Zyprexa? *

What are other side effects people have besides Intermittent explosive disorder? *

Agitation (state of anxiety or nervous excitement): 6 people, 50.00%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 5 people, 41.67%
Irritability: 5 people, 41.67%
Tardive Dyskinesia (a disorder that involves involuntary movements): 5 people, 41.67%
Suicidal Ideation: 5 people, 41.67%
Nightmares (unpleasant dreams): 4 people, 33.33%
Insomnia (sleeplessness): 4 people, 33.33%
Diabetes: 4 people, 33.33%
Drowsiness: 4 people, 33.33%
Mood Swings (an extreme or rapid change in mood): 4 people, 33.33%

What are the existing conditions these people have? *

Affective Disorder (mental disorder): 3 people, 25.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 16.67%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 16.67%
Psychotic Disorder: 2 people, 16.67%
Migraine (headache): 2 people, 16.67%
Memory Loss: 2 people, 16.67%
Insomnia (sleeplessness): 2 people, 16.67%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 16.67%
Impulsive Behavior: 1 person, 8.33%
Hallucinations (sensations that appear real but are created by your mind): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Zyprexa and have Intermittent explosive disorder?

- Check whether Intermittent explosive disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zyprexa:

Zyprexa (64,724 reports)

Browse all side effects of Zyprexa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intermittent explosive disorder:

Intermittent explosive disorder (12 drugs)

Browse all the conditions that are associated with Intermittent explosive disorder:

Intermittent explosive disorder (111 conditions)

Related publications that referenced our studies

Gupta SK, Shwetank B, "Reversible bilateral sensori-neural hearing loss due to olanzapine in a male suffering from bipolar affective disorder", Indian journal of pharmacology, 2014 Jan .
Og?odek E, Szota A, Araszkiewicz A, "Olanzapine-induced neuroleptic malignant syndrome after 10 years of treatment", Aust NZJ Psychiatry, 2013 Oct .
Gupta SK, Shwetank B, "Reversible bilateral sensori-neural hearing loss due to olanzapine in a male suffering from bipolar affective disorder", Indian journal of pharmacology, 2014 Jan .
Og?odek E, Szota A, Araszkiewicz A, "Olanzapine-induced neuroleptic malignant syndrome after 10 years of treatment", Aust NZJ Psychiatry, 2013 Oct .

How the study uses the data?

The study uses data from the FDA. It is based on olanzapine (the active ingredients of Zyprexa) and Zyprexa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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