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Zyprexa and Water intoxication - a phase IV clinical study of FDA data

Summary:

Water intoxication is reported as a side effect among people who take Zyprexa (olanzapine), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Risperidone, and have Schizophrenia.

The phase IV clinical study analyzes which people have Water intoxication when taking Zyprexa. It is created by eHealthMe based on reports of 63,412 people who have side effects when taking Zyprexa from the FDA, and is updated regularly.

What is Zyprexa?

Zyprexa has active ingredients of olanzapine. It is often used in bipolar disorder. eHealthMe is studying from 64,724 Zyprexa users. Check the latest studies of Zyprexa.

What is Water intoxication?

Water intoxication (water poisoning) is found to be associated with 79 drugs and 347 conditions by eHealthMe. Check the latest studies of Water intoxication.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

63,412 people reported to have side effects when taking Zyprexa.
Among them, 65 people (0.1%) have Water intoxication.

Could Zyprexa cause Water intoxication?

Among these 65 people:

How long have people been on Zyprexa when they have Water intoxication? *

  • < 1 month: 29.17 %
  • 1 - 6 months: 25.0 %
  • 6 - 12 months: 20.83 %
  • 1 - 2 years: 8.33 %
  • 2 - 5 years: 12.5 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 4.17 %

What is the gender of people who have Water intoxication when taking Zyprexa? *

  • female: 40.98 %
  • male: 59.02 %

What is the age of people who have Water intoxication when taking Zyprexa? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 10.91 %
  • 30-39: 23.64 %
  • 40-49: 20.0 %
  • 50-59: 23.64 %
  • 60+: 21.82 %

What are other drugs people take besides Zyprexa? *

  1. Abilify: 4 people, 6.15%
  2. Akineton: 4 people, 6.15%
  3. Halcion: 4 people, 6.15%
  4. Haloperidol: 4 people, 6.15%
  5. Lorazepam: 4 people, 6.15%
  6. Risperidone: 4 people, 6.15%
  7. Quetiapine Fumarate: 3 people, 4.62%
  8. Invega: 3 people, 4.62%
  9. Aspirin: 2 people, 3.08%
  10. Zoloft: 2 people, 3.08%

What are other side effects people have besides Water intoxication? *

  1. Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 24 people, 36.92%
  2. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 16 people, 24.62%
  3. Thirst - Excessive: 14 people, 21.54%
  4. Depressed Level Of Consciousness: 12 people, 18.46%
  5. Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 10 people, 15.38%
  6. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 8 people, 12.31%
  7. Weight Increased: 8 people, 12.31%
  8. Blood Creatine Phosphokinase Increased: 7 people, 10.77%
  9. Blood Glucose Increased: 6 people, 9.23%
  10. Blood Sodium Decreased: 6 people, 9.23%

What are the existing conditions these people have? *

  1. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 33 people, 50.77%
  2. Insomnia (sleeplessness): 3 people, 4.62%
  3. Adjustment Disorder: 3 people, 4.62%
  4. Schizophrenia, Residual Type (a condition manifested by individuals with symptoms of schizophrenia who, after a psychotic schizophrenic episode, are no longer psychotic): 2 people, 3.08%
  5. Depressive Symptom: 2 people, 3.08%
  6. Toothaches (tooth pain): 1 person, 1.54%
  7. Schizophrenia, Undifferentiated Type (a type characterized by the presence of prominent psychotic symptoms but not classifiable as catatonic, disorganized, or paranoid): 1 person, 1.54%
  8. Nasopharyngitis (inflammation of the nasopharynx): 1 person, 1.54%
  9. Intervertebral Disc Protrusion (spinal disc protrusion): 1 person, 1.54%
  10. Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 1 person, 1.54%

* Approximation only. Some reports may have incomplete information.

Do you take Zyprexa and have Water intoxication?

- Check whether Water intoxication is associated with a drug or a condition
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- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zyprexa:

Water intoxication treatments and more:

How severe was Water intoxication and when was it recovered:

Expand to all the drugs that have ingredients of olanzapine:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zyprexa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Water intoxication:

Browse all the conditions that are associated with Water intoxication:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on olanzapine (the active ingredients of Zyprexa) and Zyprexa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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