Depression in Codeine - how severe and when it was recovered? (a real world drug study)

Summary:

We study how severe was Depression, when it was recovered, drug effectiveness, race, and more among people who take Codeine (codeine sulfate). This phase IV clinical study is created by eHealthMe based on reports submitted to eHealthMe, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Depression?

Depression is found to be associated with 3,215 drugs and 4,067 conditions by eHealthMe. Check the latest studies of Depression.

On Sep, 26, 2025

23 people who have Depression while taking Codeine were studied.

Severity of Depression *:

least: 0.0 %
moderate: 38.1 %
severe: 57.14 %
most severe: 4.76 %

When people recovered from Depression *:

while on drug: 0.0 %
after off the drug: 36.36 %
not yet: 63.64 %

Effectiveness of Codeine *:

not at all: 0.0 %
somewhat: 25.0 %
moderate: 31.25 %
high: 31.25 %
very high: 12.5 %

Race of the people *:

African American, Non-Hispanic: 0.0 %
American Indian/Alaska Native: 0.0 %
Asian: 0.0 %
Hispanic: 0.0 %
Native Hawaiians/Pacific Islanders: 0.0 %
Two or more races: 0.0 %
White, Non-Hispanic: 100 %

Time on Codeine *:

Gender of people when taking Codeine *:

female: 56.52 %
male: 43.48 %

Age of people when taking Codeine *:

Conditions people have *:

Stress And Anxiety: 5 people, 21.74%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.04%
Insomnia (sleeplessness): 3 people, 13.04%
Allergic Rhinitis: 2 people, 8.70%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 8.70%
Parkinson's Disease: 2 people, 8.70%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 4.35%
Diarrhea Aggravated: 1 person, 4.35%
Gastroesophageal Reflux In Infants (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 4.35%
Gastric Ulcer (stomach ulcer): 1 person, 4.35%

Other drugs people take besides Codeine *:

Omeprazole: 3 people, 13.04%
Paracetamol: 3 people, 13.04%
Diazepam: 3 people, 13.04%
Mirtazapine: 2 people, 8.70%
Cetirizine Hydrochloride: 2 people, 8.70%
Xanax: 2 people, 8.70%
Pantoprazole: 2 people, 8.70%
Sertraline: 2 people, 8.70%
Requip: 2 people, 8.70%
Vitamin D: 2 people, 8.70%

Other side effects people have besides Depression *:

Stress And Anxiety: 5 people, 21.74%
Fatigue (feeling of tiredness): 4 people, 17.39%
Night Sweats (sweating in night): 4 people, 17.39%
Dizziness: 3 people, 13.04%
Insomnia (sleeplessness): 3 people, 13.04%
Relationship Breakdown: 2 people, 8.70%
Nausea (feeling of having an urge to vomit): 2 people, 8.70%
Post-Traumatic Stress Disorder: 2 people, 8.70%
Mood Swings (an extreme or rapid change in mood): 2 people, 8.70%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Depression?

Check whether Depression is associated with a drug or a condition

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Depression in Codeine

How the study uses the data?

The study is based on codeine sulfate (the active ingredients of Codeine). Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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