Insomnia in Divigel - how severe and when it was recovered? (a real world drug study)

Summary:

We study how severe was Insomnia, when it was recovered, drug effectiveness, race, and more among people who take Divigel (estradiol). This phase IV clinical study is created by eHealthMe based on reports submitted to eHealthMe, and is updated regularly.

What is Divigel?

Divigel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 894 Divigel users. Check the latest studies of Divigel.

What is Insomnia?

Insomnia (sleeplessness) is found to be associated with 3,115 drugs and 5,173 conditions by eHealthMe. Check the latest studies of Insomnia.

On Aug, 13, 2026

77 people who have Insomnia while taking Divigel were studied.

Severity of Insomnia *:

least: 0.0 %
moderate: 40.85 %
severe: 43.66 %
most severe: 15.49 %

When people recovered from Insomnia *:

while on drug: 0.0 %
after off the drug: 26.53 %
not yet: 73.47 %

Effectiveness of Divigel *:

not at all: 1.75 %
somewhat: 15.79 %
moderate: 26.32 %
high: 45.61 %
very high: 10.53 %

Race of the people *:

African American, Non-Hispanic: 1.64 %
American Indian/Alaska Native: 0.0 %
Asian: 1.64 %
Hispanic: 3.28 %
Native Hawaiians/Pacific Islanders: 0.0 %
Two or more races: 1.64 %
White, Non-Hispanic: 91.8 %

Time on Divigel *:

Gender of people when taking Divigel *:

female: 100 %
male: 0.0 %

Age of people when taking Divigel *:

Conditions people have *:

Depression: 21 people, 27.27%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 21 people, 27.27%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 20.78%
Stress And Anxiety: 13 people, 16.88%
High Blood Cholesterol: 12 people, 15.58%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 9 people, 11.69%
Pain: 8 people, 10.39%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 6 people, 7.79%
High Blood Pressure: 6 people, 7.79%
Migraine (headache): 5 people, 6.49%

Other drugs people take besides Divigel *:

Other side effects people have besides Insomnia *:

Fatigue (feeling of tiredness): 17 people, 22.08%
Depression: 13 people, 16.88%
Stress And Anxiety: 11 people, 14.29%
Nausea (feeling of having an urge to vomit): 8 people, 10.39%
Joint Pain: 7 people, 9.09%
Headache (pain in head): 6 people, 7.79%
Constipation: 6 people, 7.79%
Migraine (headache): 5 people, 6.49%
Weight Increased: 5 people, 6.49%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 5 people, 6.49%

* Approximation only. Some reports may have incomplete information.

Do you take Divigel and have Insomnia?

Check whether Insomnia is associated with a drug or a condition

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Insomnia in Divigel

How the study uses the data?

The study is based on estradiol (the active ingredients of Divigel). Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.