Sleeping difficulty in Protopic - how severe and when it was recovered? (a real world drug study)

Summary:

We study how severe was Sleeping difficulty, when it was recovered, drug effectiveness, race, and more among people who take Protopic (tacrolimus). This phase IV clinical study is created by eHealthMe based on reports submitted to eHealthMe, and is updated regularly.

What is Protopic?

Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.

What is Sleeping difficulty?

Sleeping difficulty (difficult sleeping) is found to be associated with 4,139 drugs and 5,376 conditions by eHealthMe. Check the latest studies of Sleeping difficulty.



On Apr, 14, 2026

13 people who have Sleeping difficulty while taking Protopic were studied.

Could Protopic cause Sleeping difficulty?

Severity of Sleeping difficulty *:

  • least: 7.69 %
  • moderate: 38.46 %
  • severe: 46.15 %
  • most severe: 7.69 %

When people recovered from Sleeping difficulty *:

  • while on drug: 0.0 %
  • after off the drug: 0.0 %
  • not yet: 100 %

Effectiveness of Protopic *:

  • not at all: 0.0 %
  • somewhat: 25.0 %
  • moderate: 0.0 %
  • high: 37.5 %
  • very high: 37.5 %

Race of the people *:

  • African American, Non-Hispanic: 0.0 %
  • American Indian/Alaska Native: 0.0 %
  • Asian: 0.0 %
  • Hispanic: 0.0 %
  • Native Hawaiians/Pacific Islanders: 0.0 %
  • Two or more races: 11.11 %
  • White, Non-Hispanic: 88.89 %

Time on Protopic *:

  • < 1 month: 9.09 %
  • 1 - 6 months: 18.18 %
  • 6 - 12 months: 18.18 %
  • 1 - 2 years: 9.09 %
  • 2 - 5 years: 27.27 %
  • 5 - 10 years: 9.09 %
  • 10+ years: 9.09 %

Gender of people when taking Protopic *:

  • female: 53.85 %
  • male: 46.15 %

Age of people when taking Protopic *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 7.69 %
  • 20-29: 7.69 %
  • 30-39: 23.08 %
  • 40-49: 7.69 %
  • 50-59: 15.38 %
  • 60+: 38.46 %

Conditions people have *:

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 30.77%
  2. High Blood Pressure: 3 people, 23.08%
  3. Hair Loss: 2 people, 15.38%
  4. Depression: 2 people, 15.38%
  5. Allergies: 2 people, 15.38%
  6. Psoriatic Arthritis (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 7.69%
  7. Hashimoto's Encephalopathy (chronic lymphocytic thyroiditis): 1 person, 7.69%
  8. Arteriosclerosis Of The Extremities (thickening and hardening of arteries- legs and feet): 1 person, 7.69%
  9. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 7.69%
  10. Autoimmune Hepatitis: 1 person, 7.69%

Other drugs people take besides Protopic *:

  1. Myfortic: 4 people, 30.77%
  2. Prednisone: 4 people, 30.77%
  3. Biotin: 2 people, 15.38%
  4. Metoprolol Tartrate: 2 people, 15.38%
  5. Gabapentin: 2 people, 15.38%
  6. Mycophenolate Mofetil: 2 people, 15.38%
  7. Ropinirole Hydrochloride: 2 people, 15.38%
  8. Calcium Carbonate, Famotidine And Magnesium Hydroxide: 1 person, 7.69%
  9. Cellcept: 1 person, 7.69%
  10. Montelukast Sodium: 1 person, 7.69%

Other side effects people have besides Sleeping difficulty *:

  1. Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 23.08%
  2. Fatigue (feeling of tiredness): 2 people, 15.38%
  3. Stress And Anxiety: 2 people, 15.38%
  4. Memory Loss: 2 people, 15.38%
  5. Weight Increased: 1 person, 7.69%
  6. Anemia (less than the normal quantity of haemoglobin in the blood): 1 person, 7.69%
  7. Arrhythmias (irregular heartbeat): 1 person, 7.69%
  8. Chills (felling of cold): 1 person, 7.69%
  9. Dehydration (dryness resulting from the removal of water): 1 person, 7.69%
  10. Depression: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Protopic and have Sleeping difficulty?

Check whether Sleeping difficulty is associated with a drug or a condition

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

How the study uses the data?

The study is based on tacrolimus (the active ingredients of Protopic). Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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