Headache in Suboxone - how severe and when it was recovered? (a real world drug study)

Summary:

We study how severe was Headache, when it was recovered, drug effectiveness, race, and more among people who take Suboxone (buprenorphine hydrochloride; naloxone hydrochloride). This phase IV clinical study is created by eHealthMe based on reports submitted to eHealthMe, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Headache?

Headache (pain in head) is found to be associated with 3,754 drugs and 5,772 conditions by eHealthMe. Check the latest studies of Headache.

On Aug, 02, 2026

66 people who have Headache while taking Suboxone were studied.

Severity of Headache *:

least: 10.53 %
moderate: 42.11 %
severe: 40.35 %
most severe: 7.02 %

When people recovered from Headache *:

while on drug: 13.89 %
after off the drug: 13.89 %
not yet: 72.22 %

Effectiveness of Suboxone *:

not at all: 1.92 %
somewhat: 5.77 %
moderate: 30.77 %
high: 32.69 %
very high: 28.85 %

Race of the people *:

African American, Non-Hispanic: 1.79 %
American Indian/Alaska Native: 1.79 %
Asian: 0.0 %
Hispanic: 3.57 %
Native Hawaiians/Pacific Islanders: 0.0 %
Two or more races: 3.57 %
White, Non-Hispanic: 89.29 %

Time on Suboxone *:

Gender of people when taking Suboxone *:

female: 77.27 %
male: 22.73 %

Age of people when taking Suboxone *:

Conditions people have *:

Depression: 14 people, 21.21%
Pain: 10 people, 15.15%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 9 people, 13.64%
Stress And Anxiety: 8 people, 12.12%
Insomnia (sleeplessness): 7 people, 10.61%
Birth Control: 4 people, 6.06%
Constipation: 4 people, 6.06%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 6.06%
High Blood Cholesterol: 3 people, 4.55%
Back Pain: 3 people, 4.55%

Other drugs people take besides Suboxone *:

Other side effects people have besides Headache *:

Nausea (feeling of having an urge to vomit): 11 people, 16.67%
Fatigue (feeling of tiredness): 6 people, 9.09%
Stress And Anxiety: 6 people, 9.09%
Nausea And Vomiting: 6 people, 9.09%
Constipation: 5 people, 7.58%
Dizziness: 5 people, 7.58%
Drowsiness: 5 people, 7.58%
Neck Pain: 5 people, 7.58%
Depression: 4 people, 6.06%
Muscle Aches (muscle pain): 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Suboxone and have Headache?

Check whether Headache is associated with a drug or a condition

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Headache in Suboxone

How the study uses the data?

The study is based on buprenorphine hydrochloride; naloxone hydrochloride (the active ingredients of Suboxone). Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.