Depression in Trazodone hydrochloride - how severe and when it was recovered? (a real world drug study)

Summary:

We study how severe was Depression, when it was recovered, drug effectiveness, race, and more among people who take Trazodone hydrochloride (trazodone hydrochloride). This phase IV clinical study is created by eHealthMe based on reports submitted to eHealthMe, and is updated regularly.

What is Trazodone hydrochloride?

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 23,016 Trazodone hydrochloride users. Check the latest studies of Trazodone hydrochloride.

What is Depression?

Depression is found to be associated with 3,167 drugs and 4,128 conditions by eHealthMe. Check the latest studies of Depression.



On Aug, 08, 2026

209 people who have Depression while taking Trazodone hydrochloride were studied.

Could Trazodone hydrochloride cause Depression?

Severity of Depression *:

  • least: 4.81 %
  • moderate: 39.04 %
  • severe: 45.99 %
  • most severe: 10.16 %

When people recovered from Depression *:

  • while on drug: 0.74 %
  • after off the drug: 29.63 %
  • not yet: 69.63 %

Effectiveness of Trazodone hydrochloride *:

  • not at all: 3.68 %
  • somewhat: 19.63 %
  • moderate: 36.81 %
  • high: 28.83 %
  • very high: 11.04 %

Race of the people *:

  • African American, Non-Hispanic: 1.14 %
  • American Indian/Alaska Native: 0.57 %
  • Asian: 1.7 %
  • Hispanic: 4.55 %
  • Native Hawaiians/Pacific Islanders: 0.0 %
  • Two or more races: 2.27 %
  • White, Non-Hispanic: 89.77 %

Time on Trazodone hydrochloride *:

  • < 1 month: 7.78 %
  • 1 - 6 months: 13.89 %
  • 6 - 12 months: 8.33 %
  • 1 - 2 years: 15.0 %
  • 2 - 5 years: 23.89 %
  • 5 - 10 years: 19.44 %
  • 10+ years: 11.67 %

Gender of people when taking Trazodone hydrochloride *:

  • female: 80.38 %
  • male: 19.62 %

Age of people when taking Trazodone hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 1.91 %
  • 20-29: 11.0 %
  • 30-39: 15.79 %
  • 40-49: 25.36 %
  • 50-59: 24.4 %
  • 60+: 21.53 %

Conditions people have *:

  1. Stress And Anxiety: 74 people, 35.41%
  2. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 38 people, 18.18%
  3. Pain: 22 people, 10.53%
  4. High Blood Pressure: 21 people, 10.05%
  5. High Blood Cholesterol: 20 people, 9.57%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 19 people, 9.09%
  7. Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 15 people, 7.18%
  8. Bipolar Disorder (mood disorder): 14 people, 6.70%
  9. Allergies: 13 people, 6.22%
  10. Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 12 people, 5.74%

Other drugs people take besides Trazodone hydrochloride *:

  1. Gabapentin: 26 people, 12.44%
  2. Vitamin D: 20 people, 9.57%
  3. Cymbalta: 19 people, 9.09%
  4. Xanax: 18 people, 8.61%
  5. Wellbutrin: 18 people, 8.61%
  6. Clonazepam: 15 people, 7.18%
  7. Zoloft: 14 people, 6.70%
  8. Lamictal: 14 people, 6.70%
  9. Prozac: 14 people, 6.70%
  10. Vyvanse: 14 people, 6.70%

Other side effects people have besides Depression *:

  1. Stress And Anxiety: 77 people, 36.84%
  2. Fatigue (feeling of tiredness): 25 people, 11.96%
  3. Migraine (headache): 21 people, 10.05%
  4. Memory Loss: 14 people, 6.70%
  5. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 13 people, 6.22%
  6. High Blood Pressure: 13 people, 6.22%
  7. Post-Traumatic Stress Disorder: 13 people, 6.22%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 6.22%
  9. Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 12 people, 5.74%
  10. Headache (pain in head): 10 people, 4.78%

* Approximation only. Some reports may have incomplete information.

Do you take Trazodone hydrochloride and have Depression?

Check whether Depression is associated with a drug or a condition

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

How the study uses the data?

The study is based on trazodone hydrochloride (the active ingredients of Trazodone hydrochloride). Other drugs that have the same active ingredients (e.g. generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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