Actoplus met vs. Lipitor: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Actoplus met and Lipitor. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 583,391 people who take Actoplus met and Lipitor, and is updated regularly.
What is Actoplus met?
Actoplus met has active ingredients of metformin hydrochloride; pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 1,210 Actoplus met users. Check the latest studies of Actoplus met.
What is Lipitor?
Lipitor has active ingredients of atorvastatin calcium. It is often used in high blood cholesterol. eHealthMe is studying from 259,048 Lipitor users. Check the latest studies of Lipitor.
eHealthMe: drug outcomes in the real world
eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.
583,391 people who take Actoplus met and Lipitor are studied.

Drugs being compared in this study:
- Lipitor (atorvastatin calcium)
- Actoplus Met (metformin hydrochloride; pioglitazone hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Actoplus Met:
- not at all: 6.25 %
- somewhat: 20.31 %
- moderate: 34.38 %
- high: 28.12 %
- very high: 10.94 %
Lipitor:
- not at all: 1.4 %
- somewhat: 10.39 %
- moderate: 30.68 %
- high: 41.87 %
- very high: 15.66 %
Want to compare Actoplus met with Lipitor?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Proti? D, Balti? S, Stupar N, Pavlov-Dolijanovi? S, Mugo?a S, Todorovi? Z, "A case of myositis with immunological background associated with statin use", Open Medicine, 2014 Oct .
- Goldie MP, "Atorvastatin: a new treatment for periodontal disease?", , 2012 Jan .
- Proti? D, Balti? S, Stupar N, Pavlov-Dolijanovi? S, Mugo?a S, Todorovi? Z, "A case of myositis with immunological background associated with statin use", Open Medicine, 2014 Oct .
- Goldie MP, "Atorvastatin: a new treatment for periodontal disease?", , 2012 Jan .
Related studies
Alternative drugs to, pros and cons of:
- Actoplus met (1,114 reports)
- Lipitor (251,219 reports)
Browse all side effects of Actoplus met:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Lipitor:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on metformin hydrochloride; pioglitazone hydrochloride and atorvastatin calcium (the active ingredients of Actoplus met and Lipitor, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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