Adapalene vs. Oracea: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Adapalene and Oracea. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 197,735 people who take Adapalene and Oracea, and is updated regularly.
What is Adapalene?
Adapalene has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 174,662 Adapalene users. Check the latest studies of Adapalene.
What is Oracea?
Oracea has active ingredients of doxycycline. It is often used in rosacea. eHealthMe is studying from 1,272 Oracea users. Check the latest studies of Oracea.
eHealthMe: drug outcomes in the real world
eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.
197,735 people who take Adapalene and Oracea are studied.

Drugs being compared in this study:
- Adapalene (adapalene)
- Oracea (doxycycline)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Adapalene:
- not at all: 6.9 %
- somewhat: 34.48 %
- moderate: 37.93 %
- high: 13.79 %
- very high: 6.9 %
Oracea:
- not at all: 8.37 %
- somewhat: 27.49 %
- moderate: 39.04 %
- high: 17.53 %
- very high: 7.57 %
Want to compare Adapalene with Oracea?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Dmour HH, Zayadeen AR, Shawagfeh JS, "Effect of Long Term Prophylaxis of Antimalarial Drug (Doxycycline) on Liver Span by Ultrasound", Middle East Journal of Internal Medicine, 2013 Jan .
- Dmour HH, Zayadeen AR, Shawagfeh JS, "Effect of Long Term Prophylaxis of Antimalarial Drug (Doxycycline) on Liver Span by Ultrasound", Middle East Journal of Internal Medicine, 2013 Jan .
Related studies
Alternative drugs to, pros and cons of:
Browse all side effects of Adapalene:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Oracea:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on adapalene and doxycycline (the active ingredients of Adapalene and Oracea, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- Nexplanon and Blister for Women aged 20-29 - 5 seconds ago
- Clarithromycin and Meropenem drug interactions for women aged 40-49 - 6 seconds ago
- Magnesium and Sodium Bicarbonate drug interactions for men aged 60+ - 7 seconds ago
- Renvela and Compazine drug interactions for men aged 60+ - 8 seconds ago
- Constipation and drugs of ingredients of mesalamine - 9 seconds ago
- Hyperlipidaemia and Myositis - 10 seconds ago
- Could Amlodipine cause Upper-Airway Cough Syndrome? - 13 seconds ago
- Could Methotrexate Sodium cause Enterobacter Sepsis? - 15 seconds ago
- Could Venlafaxine Hydrochloride cause Mucous Stools? - 37 seconds ago
- Methylprednisolone and Drowsiness for Boys aged 10-19 - 38 seconds ago