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Cafergot vs. Treximet: side effect and effectiveness comparison (a real world drug study)

Summary:

We compare the side effects and drug effectiveness of Cafergot and Treximet. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 34,162 people who take Cafergot and Treximet, and is updated regularly.

What is Cafergot?

Cafergot has active ingredients of caffeine; ergotamine tartrate. It is often used in migraine. eHealthMe is studying from 531 Cafergot users. Check the latest studies of Cafergot.

What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,904 Treximet users. Check the latest studies of Treximet.

On Aug, 05, 2026

34,162 people who take Cafergot and Treximet are studied.

Cafergot vs Treximet drug comparison reports.

Drugs being compared in this study:

  • Treximet (naproxen sodium; sumatriptan succinate)
  • Cafergot (caffeine; ergotamine tartrate)

Most common side effects of the drugs, overall:

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Most common side effects of the drugs, in long term (1+ years) use:

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Drug effectiveness:

Cafergot:

  • not at all: 0 %
  • somewhat: 8.33 %
  • moderate: 33.33 %
  • high: 8.33 %
  • very high: 50.0 %

Treximet:

  • not at all: 2.96 %
  • somewhat: 17.78 %
  • moderate: 23.7 %
  • high: 37.78 %
  • very high: 17.78 %

Want to compare Cafergot with Treximet?

- Personalize this study to your gender and age (0-99+)

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Alternative drugs to, pros and cons of:

Browse all side effects of Cafergot:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Treximet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study is based on caffeine; ergotamine tartrate and naproxen sodium; sumatriptan succinate (the active ingredients of Cafergot and Treximet, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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