Duragesic-75 vs. Tramadol hydrochloride and acetaminophen: side effect and effectiveness comparison (a real world drug study)

Summary:

We compare the side effects and drug effectiveness of Duragesic-75 and Tramadol hydrochloride and acetaminophen. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 165,763 people who take Duragesic-75 and Tramadol hydrochloride and acetaminophen, and is updated regularly.

What is Duragesic-75?

Duragesic-75 has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 94 Duragesic-75 users. Check the latest studies of Duragesic-75.

What is Tramadol hydrochloride and acetaminophen?

Tramadol hydrochloride and acetaminophen has active ingredients of acetaminophen; tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 1,382 Tramadol hydrochloride and acetaminophen users. Check the latest studies of Tramadol hydrochloride and acetaminophen.



On Aug, 05, 2026

165,763 people who take Duragesic-75 and Tramadol hydrochloride and acetaminophen are studied.

Duragesic-75 vs Tramadol hydrochloride and acetaminophen drug comparison reports.

Drugs being compared in this study:

  • Duragesic-75 (fentanyl)
  • Tramadol Hydrochloride And Acetaminophen (acetaminophen; tramadol hydrochloride)

Most common side effects of the drugs, overall:

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Most common side effects of the drugs, in long term (1+ years) use:

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Drug effectiveness:

Duragesic-75:

  • not at all: 2.03 %
  • somewhat: 19.46 %
  • moderate: 38.58 %
  • high: 29.44 %
  • very high: 10.49 %

Tramadol Hydrochloride And Acetaminophen:

  • not at all: 4.51 %
  • somewhat: 27.05 %
  • moderate: 43.44 %
  • high: 20.9 %
  • very high: 4.1 %

Want to compare Duragesic-75 with Tramadol hydrochloride and acetaminophen?

- Personalize this study to your gender and age (0-99+)

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.



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Browse all side effects of Duragesic-75:

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Browse all side effects of Tramadol hydrochloride and acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study is based on fentanyl and acetaminophen; tramadol hydrochloride (the active ingredients of Duragesic-75 and Tramadol hydrochloride and acetaminophen, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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