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Endep vs. Brintellix: side effect and effectiveness comparison (a real world drug study)

Summary:

We compare the side effects and drug effectiveness of Endep and Brintellix. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 152,609 people who take Endep and Brintellix, and is updated regularly.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

What is Brintellix?

Brintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 6,749 Brintellix users. Check the latest studies of Brintellix.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

152,609 people who take Endep and Brintellix are studied.

Endep vs Brintellix drug comparison reports.

Drugs being compared in this study:

  • Brintellix (vortioxetine hydrobromide)
  • Endep (amitriptyline hydrochloride)

Most common side effects of the drugs, overall:

Click here to view

Most common side effects of the drugs, in long term (1+ years) use:

Click here to view

Drug effectiveness:

Endep:

  • not at all: 5.7 %
  • somewhat: 26.32 %
  • moderate: 36.31 %
  • high: 23.4 %
  • very high: 8.28 %

Brintellix:

  • not at all: 5.42 %
  • somewhat: 21.9 %
  • moderate: 35.67 %
  • high: 28.22 %
  • very high: 8.8 %

Want to compare Endep with Brintellix?

- Personalize this study to your gender and age (0-99+)

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of:

Browse all side effects of Endep:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Brintellix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study is based on amitriptyline hydrochloride and vortioxetine hydrobromide (the active ingredients of Endep and Brintellix, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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