Levaquin vs. Benadryl: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Levaquin and Benadryl. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 323,112 people who take Levaquin and Benadryl, and is updated regularly.
What is Levaquin?
Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.
What is Benadryl?
Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.
323,112 people who take Levaquin and Benadryl are studied.

Drugs being compared in this study:
- Benadryl (diphenhydramine hydrochloride)
- Levaquin (levofloxacin)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Levaquin:
- not at all: 14.49 %
- somewhat: 21.66 %
- moderate: 25.11 %
- high: 31.42 %
- very high: 7.32 %
Benadryl:
- not at all: 3.18 %
- somewhat: 22.32 %
- moderate: 36.72 %
- high: 27.41 %
- very high: 10.38 %
Want to compare Levaquin with Benadryl?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Bhuvan KC, ALrasheedy AA, Ibrahim MI, "A case report from Nepalese community pharmacy on levofloxacin induced severe abdominal pain", Saudi Pharmaceutical Journal, 2013 Jul .
- MITTAL V, ARCHANA D, GUPTA A, SRIVASTAV U, CHANDRA V, SAXENA A, AGRAWAL P, "Aphasia: a Rarest Complication with a Well Known Drug Levofloxacin", Medical Science, 2013 Jan .
- Bhuvan KC, ALrasheedy AA, Ibrahim MI, "A case report from Nepalese community pharmacy on levofloxacin induced severe abdominal pain", Saudi Pharmaceutical Journal, 2013 Jul .
- MITTAL V, ARCHANA D, GUPTA A, SRIVASTAV U, CHANDRA V, SAXENA A, AGRAWAL P, "Aphasia: a Rarest Complication with a Well Known Drug Levofloxacin", Medical Science, 2013 Jan .
Related studies
Alternative drugs to, pros and cons of:
Browse all side effects of Levaquin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Benadryl:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on levofloxacin and diphenhydramine hydrochloride (the active ingredients of Levaquin and Benadryl, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- Echinacea and Dyspnoea for Men aged 60+ - a second ago
- Echinacea and Dyspnea for Men aged 60+ - a second ago
- Simvastatin and Hypersensitivity for Men aged 50-59 - 6 seconds ago
- Milk Of Magnesia and Sudden Death for Men aged 40-49 - 6 seconds ago
- Milk Of Magnesia and Death Sudden for Men aged 40-49 - 7 seconds ago
- Milk Of Magnesia and Death for Men aged 40-49 - 7 seconds ago
- Could Enalapril Maleate cause Oligohydramnios? - 9 seconds ago
- Drug interactions of Amlodipine Besylate and Diovan - 9 seconds ago
- Diphenhydramine Hydrochloride vs. Methylphenidate Hydrochloride, side effect and effectiveness comparison - 12 seconds ago
- Injection Site Mass and drugs of ingredients of metformin hydrochloride - 12 seconds ago