Suboxone vs. Methadose: side effect and effectiveness comparison (a real world drug study)

Summary:

We compare the side effects and drug effectiveness of Suboxone and Methadose. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 102,445 people who take Suboxone and Methadose, and is updated regularly.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

What is Methadose?

Methadose has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 5,101 Methadose users. Check the latest studies of Methadose.



On Apr, 20, 2026

102,445 people who take Suboxone and Methadose are studied.

Suboxone vs Methadose drug comparison reports.

Drugs being compared in this study:

  • Suboxone (buprenorphine hydrochloride; naloxone hydrochloride)
  • Methadose (methadone hydrochloride)

Most common side effects of the drugs, overall:

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Most common side effects of the drugs, in long term (1+ years) use:

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Drug effectiveness:

Suboxone:

  • not at all: 1.25 %
  • somewhat: 9.2 %
  • moderate: 22.16 %
  • high: 37.48 %
  • very high: 29.91 %

Methadose:

  • not at all: 2.11 %
  • somewhat: 13.66 %
  • moderate: 30.57 %
  • high: 32.93 %
  • very high: 20.73 %

Want to compare Suboxone with Methadose?

- Personalize this study to your gender and age (0-99+)

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.



Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of:

Browse all side effects of Suboxone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Methadose:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study is based on buprenorphine hydrochloride; naloxone hydrochloride and methadone hydrochloride (the active ingredients of Suboxone and Methadose, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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