Polyethylene glycol 3350 vs. Linzess: side effect and effectiveness comparison (a real world drug study)

Summary:

We compare the side effects and drug effectiveness of Polyethylene glycol 3350 and Linzess. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 136,461 people who take Polyethylene glycol 3350 and Linzess, and is updated regularly.

What is Polyethylene glycol 3350?

Polyethylene glycol 3350 has active ingredients of polyethylene glycol 3350. It is often used in constipation. eHealthMe is studying from 4,407 Polyethylene glycol 3350 users. Check the latest studies of Polyethylene glycol 3350.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.



On Jul, 09, 2026

136,461 people who take Polyethylene glycol 3350 and Linzess are studied.

Polyethylene glycol 3350 vs Linzess drug comparison reports.

Drugs being compared in this study:

  • Polyethylene Glycol 3350 (polyethylene glycol 3350)
  • Linzess (linaclotide)

Most common side effects of the drugs, overall:

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Most common side effects of the drugs, in long term (1+ years) use:

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Drug effectiveness:

Polyethylene Glycol 3350:

  • not at all: 3.51 %
  • somewhat: 18.4 %
  • moderate: 34.55 %
  • high: 29.92 %
  • very high: 13.62 %

Linzess:

  • not at all: 6.99 %
  • somewhat: 19.11 %
  • moderate: 31.93 %
  • high: 26.11 %
  • very high: 15.85 %

Want to compare Polyethylene glycol 3350 with Linzess?

- Personalize this study to your gender and age (0-99+)

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.



Related studies

Alternative drugs to, pros and cons of:

Browse all side effects of Polyethylene glycol 3350:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Linzess:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study is based on polyethylene glycol 3350 and linaclotide (the active ingredients of Polyethylene glycol 3350 and Linzess, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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