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Skyla vs. Enpresse-28: side effect and effectiveness comparison (a real world drug study)

Summary:

We compare the side effects and drug effectiveness of Skyla and Enpresse-28. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 249,041 people who take Skyla and Enpresse-28, and is updated regularly.

What is Skyla?

Skyla has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 5,452 Skyla users. Check the latest studies of Skyla.

What is Enpresse-28?

Enpresse-28 has active ingredients of ethinyl estradiol; levonorgestrel. It is often used in birth control. eHealthMe is studying from 35 Enpresse-28 users. Check the latest studies of Enpresse-28.

On Jul, 25, 2026

249,041 people who take Skyla and Enpresse-28 are studied.

Skyla vs Enpresse-28 drug comparison reports.

Drugs being compared in this study:

  • Enpresse-28 (ethinyl estradiol; levonorgestrel)
  • Skyla (levonorgestrel)

Most common side effects of the drugs, overall:

Click here to view

Most common side effects of the drugs, in long term (1+ years) use:

Click here to view

Drug effectiveness:

Skyla:

  • not at all: 2.66 %
  • somewhat: 7.2 %
  • moderate: 11.04 %
  • high: 31.56 %
  • very high: 47.53 %

Enpresse-28:

  • not at all: 0.93 %
  • somewhat: 5.14 %
  • moderate: 13.32 %
  • high: 32.83 %
  • very high: 47.78 %

Want to compare Skyla with Enpresse-28?

- Personalize this study to your gender and age (0-99+)

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Alternative drugs to, pros and cons of:

Browse all side effects of Skyla:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Enpresse-28:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study is based on levonorgestrel and ethinyl estradiol; levonorgestrel (the active ingredients of Skyla and Enpresse-28, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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