Skyla vs. Medroxyprogesterone acetate: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Skyla and Medroxyprogesterone acetate. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 295,541 people who take Skyla and Medroxyprogesterone acetate, and is updated regularly.
What is Skyla?
Skyla has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 5,452 Skyla users. Check the latest studies of Skyla.
What is Medroxyprogesterone acetate?
Medroxyprogesterone acetate has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 12,600 Medroxyprogesterone acetate users. Check the latest studies of Medroxyprogesterone acetate.
eHealthMe: drug outcomes in the real world
eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.
295,541 people who take Skyla and Medroxyprogesterone acetate are studied.

Drugs being compared in this study:
- Medroxyprogesterone Acetate (medroxyprogesterone acetate)
- Skyla (levonorgestrel)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Skyla:
- not at all: 2.51 %
- somewhat: 7.21 %
- moderate: 11.05 %
- high: 31.58 %
- very high: 47.65 %
Medroxyprogesterone Acetate:
- not at all: 3.79 %
- somewhat: 7.0 %
- moderate: 12.54 %
- high: 32.26 %
- very high: 44.41 %
Want to compare Skyla with Medroxyprogesterone acetate?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
- Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
Related studies
Alternative drugs to, pros and cons of:
- Skyla (5,414 reports)
- Medroxyprogesterone acetate (12,407 reports)
Browse all side effects of Skyla:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Medroxyprogesterone acetate:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on levonorgestrel and medroxyprogesterone acetate (the active ingredients of Skyla and Medroxyprogesterone acetate, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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