Coreg vs. Spironolactone and hydrochlorothiazide: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Coreg and Spironolactone and hydrochlorothiazide. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 161,969 people who take Coreg and Spironolactone and hydrochlorothiazide, and is updated regularly.
What is Coreg?
Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.
What is Spironolactone and hydrochlorothiazide?
Spironolactone and hydrochlorothiazide has active ingredients of hydrochlorothiazide; spironolactone. It is often used in high blood pressure. eHealthMe is studying from 567 Spironolactone and hydrochlorothiazide users. Check the latest studies of Spironolactone and hydrochlorothiazide.
161,969 people who take Coreg and Spironolactone and hydrochlorothiazide are studied.

Drugs being compared in this study:
- Spironolactone And Hydrochlorothiazide (hydrochlorothiazide; spironolactone)
- Coreg (carvedilol)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Coreg:
- not at all: 2.09 %
- somewhat: 15.18 %
- moderate: 36.2 %
- high: 34.89 %
- very high: 11.63 %
Spironolactone And Hydrochlorothiazide:
- not at all: 2.13 %
- somewhat: 19.15 %
- moderate: 34.04 %
- high: 38.3 %
- very high: 6.38 %
Want to compare Coreg with Spironolactone and hydrochlorothiazide?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
- Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
- Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
Related studies
Alternative drugs to, pros and cons of:
- Coreg (48,178 reports)
- Spironolactone and hydrochlorothiazide (548 reports)
Browse all side effects of Coreg:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Spironolactone and hydrochlorothiazide:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on carvedilol and hydrochlorothiazide; spironolactone (the active ingredients of Coreg and Spironolactone and hydrochlorothiazide, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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