Tri-sprintec vs. Loestrin 24 fe: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Tri-sprintec and Loestrin 24 fe. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 38,012 people who take Tri-sprintec and Loestrin 24 fe, and is updated regularly.
What is Tri-sprintec?
Tri-sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 1,428 Tri-sprintec users. Check the latest studies of Tri-sprintec.
What is Loestrin 24 fe?
Loestrin 24 fe has active ingredients of ethinyl estradiol; norethindrone acetate. It is often used in birth control. eHealthMe is studying from 1,234 Loestrin 24 fe users. Check the latest studies of Loestrin 24 fe.
38,012 people who take Tri-sprintec and Loestrin 24 fe are studied.

Drugs being compared in this study:
- Tri-Sprintec (ethinyl estradiol; norgestimate)
- Loestrin 24 Fe (ethinyl estradiol; norethindrone acetate)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Tri-Sprintec:
- not at all: 1.46 %
- somewhat: 6.08 %
- moderate: 11.05 %
- high: 32.65 %
- very high: 48.76 %
Loestrin 24 Fe:
- not at all: 1.76 %
- somewhat: 7.13 %
- moderate: 14.79 %
- high: 36.48 %
- very high: 39.85 %
Want to compare Tri-sprintec with Loestrin 24 fe?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related studies
Alternative drugs to, pros and cons of:
- Tri-sprintec (1,040 reports)
- Loestrin 24 fe (422 reports)
Browse all side effects of Tri-sprintec:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Loestrin 24 fe:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on ethinyl estradiol; norgestimate and ethinyl estradiol; norethindrone acetate (the active ingredients of Tri-sprintec and Loestrin 24 fe, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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