Itching and drugs of ingredients of acetylcysteine - a phase IV clinical study of FDA data


Summary:

Itching is found among people who take drugs with ingredients of acetylcysteine, especially for people who are female, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 11,053 people who have side effects when taking drugs with ingredients of acetylcysteine from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Acetadote, Acetylcysteine, Cetylev, Mucomyst, Mucosil-10, Mucosil-20.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.


On Oct, 01, 2022

11,053 people reported to have side effects when taking drugs with ingredients of acetylcysteine.
Among them, 287 people (2.6%) have Itching


What is Itching?

Itching is found to be associated with 4,194 drugs and 4,255 conditions by eHealthMe.

Number of reports submitted per year:

Could drugs with ingredients of acetylcysteine cause Itching?

Time on drugs with ingredients of acetylcysteine when people have Itching *:

  • < 1 month: 92.0 %
  • 1 - 6 months: 6.67 %
  • 6 - 12 months: 1.33 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Itching when taking drugs with ingredients of acetylcysteine *:

  • female: 57.04 %
  • male: 42.96 %

Age of people who have Itching when taking drugs with ingredients of acetylcysteine *:

  • 0-1: 1.2 %
  • 2-9: 0.8 %
  • 10-19: 8.4 %
  • 20-29: 5.6 %
  • 30-39: 9.2 %
  • 40-49: 9.6 %
  • 50-59: 13.2 %
  • 60+: 52.0 %

Conditions people have *:

  1. High Blood Pressure: 25 people, 8.71%
  2. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 19 people, 6.62%
  3. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 14 people, 4.88%
  4. Idiopathic Pulmonary Fibrosis (chronic lung disease): 13 people, 4.53%
  5. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 12 people, 4.18%
  6. Pain: 10 people, 3.48%
  7. High Blood Cholesterol: 9 people, 3.14%
  8. Overdose: 9 people, 3.14%
  9. Hypokalemia (low potassium): 9 people, 3.14%
  10. Fever: 8 people, 2.79%

Other drugs people take *:

  1. Acetaminophen: 35 people, 12.20%
  2. Tylenol: 22 people, 7.67%
  3. Heparin: 16 people, 5.57%
  4. Lasix: 15 people, 5.23%
  5. Neurontin: 14 people, 4.88%
  6. Avelox: 14 people, 4.88%
  7. Norvasc: 14 people, 4.88%
  8. Spiriva: 13 people, 4.53%
  9. Alprazolam: 13 people, 4.53%
  10. Amlodipine: 13 people, 4.53%

Other side effects people have besides Itching *:

  1. Rashes (redness): 91 people, 31.71%
  2. Fever: 48 people, 16.72%
  3. Weakness: 34 people, 11.85%
  4. Fatigue (feeling of tiredness): 33 people, 11.50%
  5. Nausea (feeling of having an urge to vomit): 32 people, 11.15%
  6. Headache (pain in head): 28 people, 9.76%
  7. Rash Maculo-Papular (red area on the skin that is covered with small confluent bumps): 28 people, 9.76%
  8. Pain: 25 people, 8.71%
  9. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 23 people, 8.01%
  10. Breathing Difficulty: 20 people, 6.97%

* Approximation only. Some reports may have incomplete information.


How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Drugs with ingredients of acetylcysteine, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on acetylcysteine. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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