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Vitreous floaters and drugs of ingredients of diphenhydramine hydrochloride (a real world drug study)


Summary:

Vitreous floaters is found among people who take drugs with ingredients of diphenhydramine hydrochloride, especially for people who are female, 60+ old , have been taking the drugs for < 1 month. This phase IV clinical study is created by eHealthMe based on reports of 209,426 people who have side effects when taking drugs with ingredients of diphenhydramine hydrochloride from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Zzzquil, Antitussive, Beldin, Belix, Benadryl, Benadryl preservative free, Benylin, Dibenil, Diphen, Diphenhydramine hydrochloride, Diphenhydramine hydrochloride preservative free, Hydramine, Silphen, Vicks formula 44.

On Nov, 26, 2025

209,426 people reported to have side effects when taking drugs with ingredients of diphenhydramine hydrochloride.
Among them, 236 people (0.11%) have Vitreous floaters

What is Vitreous floaters?

Vitreous floaters (spots before the eyes) is found to be associated with 886 drugs and 826 conditions by eHealthMe. Check the latest studies of Vitreous floaters.

Number of reports submitted per year:

Could drugs with ingredients of diphenhydramine hydrochloride cause Vitreous floaters?

Time on drugs with ingredients of diphenhydramine hydrochloride when people have Vitreous floaters *:

  • < 1 month: 75.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 16.67 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 8.33 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Vitreous floaters when taking drugs with ingredients of diphenhydramine hydrochloride *:

  • female: 70.35 %
  • male: 29.65 %

Age of people who have Vitreous floaters when taking drugs with ingredients of diphenhydramine hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 2.44 %
  • 20-29: 3.66 %
  • 30-39: 6.1 %
  • 40-49: 13.41 %
  • 50-59: 26.22 %
  • 60+: 48.17 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. High Blood Pressure: 51 people, 21.61%
  2. Multiple Myeloma (cancer of the plasma cells): 27 people, 11.44%
  3. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 22 people, 9.32%
  4. Breast Cancer: 21 people, 8.90%
  5. Metastases To Bone (cancer spreads to bone): 21 people, 8.90%
  6. Depression: 19 people, 8.05%
  7. Diabetes: 19 people, 8.05%
  8. Diarrhea: 19 people, 8.05%
  9. Seasonal Allergy (allergic condition due to certain season): 17 people, 7.20%
  10. High Blood Cholesterol: 17 people, 7.20%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Zometa: 73 people, 30.93%
  2. Prednisone: 54 people, 22.88%
  3. Acyclovir: 53 people, 22.46%
  4. Protonix: 52 people, 22.03%
  5. Hydrochlorothiazide: 44 people, 18.64%
  6. Allegra: 42 people, 17.80%
  7. Aredia: 41 people, 17.37%
  8. Neurontin: 40 people, 16.95%
  9. Aspirin: 39 people, 16.53%
  10. Toprol-Xl: 39 people, 16.53%

Other side effects people have besides Vitreous floaters *:

You may use this to check any potential undetected side effects.

  1. Vision Blurred: 94 people, 39.83%
  2. Fatigue (feeling of tiredness): 86 people, 36.44%
  3. Pain: 81 people, 34.32%
  4. Joint Pain: 72 people, 30.51%
  5. Eye Pain: 70 people, 29.66%
  6. Diarrhea: 70 people, 29.66%
  7. Nausea (feeling of having an urge to vomit): 68 people, 28.81%
  8. Osteonecrosis Of Jaw (death of bone of jaw): 68 people, 28.81%
  9. Headache (pain in head): 67 people, 28.39%
  10. Dyspnea (difficult or laboured breathing): 66 people, 27.97%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of diphenhydramine hydrochloride, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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