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Cystitis interstitial and drugs of ingredients of divalproex sodium (a real world drug study)


Summary:

Cystitis interstitial is found among people who take drugs with ingredients of divalproex sodium, especially for people who are female, 30-39 old , have been taking the drugs for 6 - 12 months. This phase IV clinical study is created by eHealthMe based on reports of 67,439 people who have side effects when taking drugs with ingredients of divalproex sodium from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Depakote, Depakote cp, Depakote er, Divalproex, Divalproex sodium, Epival.

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On Jun, 14, 2026

67,439 people reported to have side effects when taking drugs with ingredients of divalproex sodium.
Among them, 19 people (0.03%) have Cystitis interstitial

What is Cystitis interstitial?

Cystitis interstitial (unknown cause characterized by bladder pain) is found to be associated with 332 drugs and 439 conditions by eHealthMe. Check the latest studies of Cystitis interstitial.

Number of reports submitted per year:

Could drugs with ingredients of divalproex sodium cause Cystitis interstitial?

Time on drugs with ingredients of divalproex sodium when people have Cystitis interstitial *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 50 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Cystitis interstitial when taking drugs with ingredients of divalproex sodium *:

  • female: 88.89 %
  • male: 11.11 %

Age of people who have Cystitis interstitial when taking drugs with ingredients of divalproex sodium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 50.0 %
  • 40-49: 28.57 %
  • 50-59: 0.0 %
  • 60+: 21.43 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Pain: 11 people, 57.89%
  2. Nausea (feeling of having an urge to vomit): 6 people, 31.58%
  3. Stress And Anxiety: 5 people, 26.32%
  4. Hypoaesthesia (reduced sense of touch or sensation): 5 people, 26.32%
  5. Infection: 5 people, 26.32%
  6. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 26.32%
  7. Burning Sensation: 3 people, 15.79%
  8. Bladder Disorder: 3 people, 15.79%
  9. Insomnia (sleeplessness): 3 people, 15.79%
  10. Muscle Spasms (muscle contraction): 2 people, 10.53%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Flexeril: 8 people, 42.11%
  2. Zofran: 7 people, 36.84%
  3. Valium: 7 people, 36.84%
  4. Xanax: 6 people, 31.58%
  5. Ativan: 5 people, 26.32%
  6. Vivelle: 5 people, 26.32%
  7. Bactrim Ds: 5 people, 26.32%
  8. Lidocaine: 5 people, 26.32%
  9. Lunesta: 5 people, 26.32%
  10. Macrodantin: 5 people, 26.32%

Other side effects people have besides Cystitis interstitial *:

You may use this to check any potential undetected side effects.

  1. Nausea (feeling of having an urge to vomit): 8 people, 42.11%
  2. Headache (pain in head): 7 people, 36.84%
  3. Fever: 7 people, 36.84%
  4. Memory Loss: 7 people, 36.84%
  5. Pain: 6 people, 31.58%
  6. Depression: 6 people, 31.58%
  7. Tremor (trembling or shaking movements in one or more parts of your body): 6 people, 31.58%
  8. Stress And Anxiety: 5 people, 26.32%
  9. Insomnia (sleeplessness): 5 people, 26.32%
  10. Urinary Tract Infection: 5 people, 26.32%

* Approximation only. Some reports may have incomplete information.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Related studies

Drugs with ingredients of divalproex sodium, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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