Laryngeal oedema and drugs of ingredients of divalproex sodium (a real world drug study)


Summary:

Laryngeal oedema is found among people who take drugs with ingredients of divalproex sodium, especially for people who are female, 60+ old , have been taking the drugs for 6 - 12 months. This phase IV clinical study is created by eHealthMe based on reports of 67,439 people who have side effects when taking drugs with ingredients of divalproex sodium from the FDA, and is updated regularly.

Drug(s) considered in the study (i.e. both brand name and generic drugs): Depakote, Depakote cp, Depakote er, Divalproex, Divalproex sodium, Epival.


On Aug, 10, 2026

67,439 people reported to have side effects when taking drugs with ingredients of divalproex sodium.
Among them, 11 people (0.02%) have Laryngeal oedema


What is Laryngeal oedema?

Laryngeal oedema (swelling of larynx) is found to be associated with 603 drugs and 836 conditions by eHealthMe. Check the latest studies of Laryngeal oedema.

Number of reports submitted per year:

Could drugs with ingredients of divalproex sodium cause Laryngeal oedema?

Time on drugs with ingredients of divalproex sodium when people have Laryngeal oedema *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Laryngeal oedema when taking drugs with ingredients of divalproex sodium *:

  • female: 66.67 %
  • male: 33.33 %

Age of people who have Laryngeal oedema when taking drugs with ingredients of divalproex sodium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 11.11 %
  • 20-29: 22.22 %
  • 30-39: 11.11 %
  • 40-49: 11.11 %
  • 50-59: 0.0 %
  • 60+: 44.44 %

Conditions people have *:

You may use this to check any potential undetected conditions.

  1. Depression: 2 people, 18.18%
  2. Colon Cancer: 2 people, 18.18%
  3. Sleep Disorder: 1 person, 9.09%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
  5. Nausea And Vomiting: 1 person, 9.09%
  6. Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 9.09%
  7. High Blood Pressure: 1 person, 9.09%
  8. Diarrhea: 1 person, 9.09%
  9. Cerebral Artery Stenosis (hardening of brain blood vessels): 1 person, 9.09%
  10. Astrocytoma, Low Grade (low grade tumour of the brain that originate in a particular kind of glial-cells): 1 person, 9.09%

Other drugs people take *:

You may use this to check any potential interacting drugs.

  1. Claritin: 3 people, 27.27%
  2. Lipitor: 3 people, 27.27%
  3. Polaramine: 2 people, 18.18%
  4. Evista: 2 people, 18.18%
  5. Medrol: 2 people, 18.18%
  6. Decadron: 2 people, 18.18%
  7. Famotidine: 2 people, 18.18%
  8. Avastin: 2 people, 18.18%
  9. Zofran: 2 people, 18.18%
  10. Carbamazepine: 1 person, 9.09%

Other side effects people have besides Laryngeal oedema *:

You may use this to check any potential undetected side effects.

  1. Dyspnea (difficult or laboured breathing): 3 people, 27.27%
  2. Pharyngeal Oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal): 2 people, 18.18%
  3. Pain: 2 people, 18.18%
  4. Itching: 2 people, 18.18%
  5. Hypersensitivity: 2 people, 18.18%
  6. Skin Exfoliation (removal of the oldest dead skin cells): 2 people, 18.18%
  7. Gastric Disorder (disease of stomach): 2 people, 18.18%
  8. Eye Oedema (swelling or thickening of the macula, the area of the retina responsible for central vision): 2 people, 18.18%
  9. Infection: 1 person, 9.09%
  10. Ill-Defined Disorder: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.


How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

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Drugs with ingredients of divalproex sodium, their effectiveness, alternatives and more:

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium. All drugs that have the same active ingredients (e.g. brand name and generic drugs) are considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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